Results 101 to 110 of about 279,412 (303)
Advanced Science, EarlyView.Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye +9 more
wiley +1 more source
Ecology and EvolutionCorrelations between annual recovery and survival probabilities estimated from tag‐recovery data have been used to quantify the demographic response of exploited populations to harvest. Deane et al.
Cody E. Deane +5 more
doaj +1 more source
Model Comparison of Coordinate-Free Multivariate Skewed Distributions with an Application to Stochastic Frontiers [PDF]
We consider classes of multivariate distributions which can model skewness and are closed under orthogonal transformations. We review two classes of such distributions proposed in the literature and focus our attention on a particular, yet quite flexible,
Jose T.A.S. Ferreira, Mark F.J. Steel
core
Multivariate extremes at work for portfolio risk measurement [PDF]
, 2002 This paper proposes a methodology to provide risk measures for portfolios during extreme events. The approach is based on splitting the multivariate extreme value distribution of the assets of the portfolio into two parts: the distributions of each ...
Bouyé, Eric
core
Advanced Science, EarlyView.THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu +10 more
wiley +1 more source
Distribution of Distances Between Random Vectors and Two Fixed Points
MathematicsSuppose x→ and y→ are two arbitrary fixed points in d-dimensional space and Z→ is a random vector with a known probability density. It is desired in some applications to find the joint probability distribution function for the distance between x→ and Z ...
John Lawrence
doaj +1 more source
Advanced Science, EarlyView.In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu +11 more
wiley +1 more source
Frontiers in Applied Mathematics and StatisticsIn this study, we investigate the issue of estimating the mean vector of a multivariate normal distribution. We introduce two new families of shrinkage estimators derived from both the maximum likelihood estimator and the James-Stein estimator.
Najla M. ALoraini +2 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv +8 more
wiley +1 more source
Forecasting Value-at-Risk Using Block Structure Multivariate Stochastic Volatility Models [PDF]
Most multivariate variance or volatility models suffer from a common problem, the “curse of dimensionality”. For this reason, most are fitted under strong parametric restrictions that reduce the interpretation and flexibility of the models. Recently, the
Michael McAleer +2 more
core +2 more sources