Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source
Static sagittal cervical alignment, pain, and jaw functional limitation across temporomandibular disorder subtypes: a cross-sectional study. [PDF]
BMC Oral HealthKara T, Kuzu NÜ, Doğan E, Bayram D.
europepmc +1 more source
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source
Flexible outlier detection in multicenter clinical trials. [PDF]
J Clin Transl SciRigdon J +7 more
europepmc +1 more source
Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng +12 more
wiley +1 more source
Bone regeneration after transcrestal sinus lift using nanoscale super-hydrophilic versus standard implant surfaces: a single-center, 12-month, parallel controlled clinical trial. [PDF]
Oral Maxillofac SurgCanullo L +5 more
europepmc +1 more source
Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content
Advanced Science, EarlyView.Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri +3 more
wiley +1 more source
Evaluation of the Nrf2-Keap1 Pathway in Patients with Acute Cerebral Ischemic Disease. [PDF]
Medicina (Kaunas)Alkan G +4 more
europepmc +1 more source
Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis
Advanced Science, EarlyView.Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang +9 more
wiley +1 more source
Critical-Network Lesion-Symptom Mapping. [PDF]
Hum Brain MappWalker GM +6 more
europepmc +1 more source