Results 161 to 170 of about 2,628,917 (279)

Multivariate Statistics, Mineralogy, and Radiological Hazards Assessment Due to the Natural Radioactivity Content in Pyroclastic Products from Mt. Etna, Sicily, Southern Italy. [PDF]

Int J Environ Res Public Health, 2022
Caridi F, Spoto SE, Mottese AF, Paladini G, Crupi V, Belvedere A, Marguccio S, D'Agostino M, Faggio G, Grillo R, Messina G, Barreca F, Venuti V, Majolino D.   +13 more
europepmc   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Take a seed! Revealing Neolithic landscape and agricultural development in the Carpathian Basin through multivariate statistics and environmental modelling. [PDF]

PLoS One, 2021
Kempf M.
europepmc   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Assessment of Metals Concentrations in Soils of Abu Dhabi Emirate Using Pollution Indices and Multivariate Statistics. [PDF]

Toxics, 2021
Nazzal Y, Bărbulescu A, Howari F, Al-Taani AA, Iqbal J, Xavier CM, Sharma M, Dumitriu CȘ.   +7 more
europepmc   +1 more source

Local rank tests in a multivariate nonparametric relationship [PDF]

Consider a multivariate nonparametric model where the unknown vector of functions depends on two sets of explanatory variables. For a fixed level of one set of explanatory variables, we provide consistent statistical tests, called local rank tests, to ...
Natércia Fortuna
core  

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Analyze the Effect of Steaming on the Chemical Constituents, Defecation and Liver Injury of Polygonum Multiflorum Radix (Heshouwu) by Multiple Analysis Techniques Combined with Multivariate Statistics. [PDF]

Molecules, 2022
Du X, Xu L, Zhang Z, Wang Y, Li H, Cui W, Lin H.   +6 more
europepmc   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Integrating faunal and botanical remains using multivariate statistics to reconstruct (pre)historic subsistence developments. [PDF]

MethodsX, 2021
Vermeersch S, Riehl S, Starkovich BM, Kamlah J.   +3 more
europepmc   +1 more source