Results 221 to 230 of about 1,045,644 (311)

Untargeted Metabolomic Analysis Combined With Multivariate Statistics Reveal Distinct Metabolic Changes in GPR40 Agonist-Treated Animals Related to Bile Acid Metabolism. [PDF]

Front Mol Biosci, 2020
Doerfler H, Botesteanu DA, Blech S, Laux R.   +3 more
europepmc   +1 more source

Dynamic Neural Deactivation Bridges Direct and Competitive Inhibition Processes

Advanced Science, EarlyView.
Dynamic neural deactivation bridges traditionally distinct inhibitory mechanisms—direct inhibition and competition‐induced inhibition—revealing a common neural signature across modalities. Multimodal neuroimaging and behavioral experiments demonstrate a temporal dynamic characterized by progressive frontoparietal activation decay and enhanced sensory ...
Zhenhong He, Yifan Du, Ziqi Fu, Youcun Zheng, Nils Muhlert, Barbara Sahakian, Rebecca Elliott   +6 more
wiley   +1 more source

Characterizing the flavor profiles of Linjiangsi broad bean (Vicia faba L.) paste using bionic sensory and multivariate statistics analyses based on ripening time and fermentation environment. [PDF]

Food Chem X
Ping C, Deng X, Guo Z, Luo W, Li X, Xin S.   +5 more
europepmc   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

Exploring the selectivity of WO 3 with iridium catalyst in an ethanol/naphthalene mixture using multivariate statistics

, 2016
Manuel Bastuck, Donatella Puglisi, Joni Huotari, Tilman Sauerwald, Jyrki Lappalainen, Anita Lloyd Spetz, Mike Andersson, Andreas Schütze   +7 more
openalex   +2 more sources

Applying univariate vs. multivariate statistics to investigate therapeutic efficacy in (pre)clinical trials: A Monte Carlo simulation study on the example of a controlled preclinical neurotrauma trial. [PDF]

PLoS One, 2020
Todorov H, Searle-White E, Gerber S.
europepmc   +1 more source

Big Data and AI‐Powered Modeling: A Pathway to Sustainable Precision Animal Nutrition

Advanced Science, EarlyView.
This review summarizes the current landscape of big data and AI‐powered modeling in animal nutrition, covering techniques including intelligent data acquisition, data augmentation, explainable machine learning, heuristic algorithms, and life cycle assessment‐based sustainability evaluation.
Shuai Zhang, Changhua Lai, Jinbiao Zhao, Junjun Wang   +3 more
wiley   +1 more source

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

Part 1: Tracing Russian VX to its synthetic routes by multivariate statistics of chemical attribution signatures

, 2018
Karin Höjer Holmgren, Carlos A. Valdez, Roger Magnusson, Alexander K. Vu, Sandra Lindberg, Audrey M. Williams, Armando Alcaraz, Crister Åstot, Saphon Hok, Rikard Norlin   +9 more
openalex   +2 more sources

A multivariate data analysis approach for investigating daily statistics of countries affected with COVID-19 pandemic

, 2020
Ahmed Ramadan, Ahmed H. Kamel, Alaa Taha, Abdelhamid Elshabrawy, Noura Anwar Abdel-Fatah   +4 more
openalex   +1 more source