Results 111 to 120 of about 6,896,031 (290)

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Gerak Jalan Santai HUT RI 73 Civitas Akademik Universitas Medan Area

, 2018
Memperingati Hari Ulang Tahun (HUT) Republik Indonesia ke-73, segenap civitas akademika Uiversitas Medan Area (UMA) dan siswa/i SMK/SMA/Sederajat se-kota medan mengikuti acara gerak jalan santai, Kamis (16/08).
Humas, Universitas Medan Area
core   +1 more source

Municipal activities for the environment : a perspective on the Kgalagadi municipal area

, 2009
Thesis (M.
openaire   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Fe-C Micro-Electrolysis of HMX: Performance Optimization, Degradation Mechanisms, and Toxicity Evolution Revealed by Toxicogenomics-Based Assay

Toxics
This study evaluated the degradation of 1,3,5,7-tetranitro-1,3,5,7-tetrazocane (HMX) in simulated wastewater using an iron-carbon (Fe-C) micro-electrolysis system. The treatment efficiency was systematically evaluated under varying initial pH, Fe dosage,
Xin Jiang, Dongqi Wang, Guodong Chai, Guangxiang Duan, Haoting Xiong, Yishi Qian, Lin Xie, Yi Xiao, Heyun Yang, Mingrui Fan, Jiake Li, Yishan Lin, Xiaoliang Li, Yuling Liu   +13 more
doaj   +1 more source

Municipalities in rural areas face challenges

, 2019
Do municipal mergers affect the democratic development at the local level? Numerous countries initiated municipal reforms in order to increase efficiency, administrative quality, and cost savings. Existing research focuses on the effect on local economic efficiency or political efficacy.
Heinisch R., Lehner T., Mühlböck A.,, Reinhard, Lehner, Thomas, Mühlböck, Armin   +2 more
openaire   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Analysis of cost and effectiveness of treatment in benign paroxysmal positional vertigo

Chinese Medical Journal, 2019
Ya-Li Wang, Min-Ya Wu, Pei-Li Cheng, Shao-Fang Pei, Yi Liu, Ying-Mei Liu, Yuan-Yuan Ji   +6 more
doaj   +1 more source

Household secondhand smoke exposure and its influencing factors among pregnant women in the Pudong New Area of Shanghai, 2024: a cross-sectional survey

Zhongguo gonggong weisheng
ObjectiveTo investigate the prevalence and influencing factors of household secondhand smoke (SHS) exposure among urban and rural pregnant women in Pudong New Area, Shanghai, and to provide evidence for developing targeted smoking control and ...
Ling HUANG, Lei GUO, Mengyuan DING, Qian WU, Jiangyu XIAO, Yuxin JIANG, De CHEN, Siyu YU   +7 more
doaj   +1 more source