Results 111 to 120 of about 255,065 (314)

A Deep Reinforcement Learning Approach to Enhancing Liquidity in the U.S. Municipal Bond Market: An Intelligent Agent-based Trading System

Journal of Advanced Computing Systems
This paper presents a new approach to improve revenue in the US bond market using deep learning (DRL) as an artificial intelligence-based market. This study addresses the persistent lack of capacity in this critical business by combining advanced ...
Keke Yu ,  Qi Shen, Qi Lou, Yitian Zhang, Xin Ni   +4 more
doaj   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Bonded by duty: The impact of training on police canine-handler partnerships and public safety

Human-Animal Interactions
Background: Police canines (K9s) provide valuable support to many local law enforcement agencies and are recognized for their roles in community policing and public safety.
Madison Slane, Meera Gatlin
doaj   +1 more source

2007 Charter School Facility Finance Landscape [PDF]

, 2007
Provides a roadmap for individual schools as they attempt to navigate the charter school facility landscape, and a policy guide for those interested in helping to rationalize the sector and develop more equitable funding for charter school ...
Clara Chae, Elise Balboni, Eva Rainer, Kathy Olsen   +3 more
core  

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Saving Special Places: Community Funding for Land Conservation [PDF]

, 2002
In New Hampshire communities, there is a groundswell of interest and activity in conserving land. New Hampshire currently has more than forty-five land trusts. There are conservation commissions in all but a handful of towns.
Hart, Brian, Taylor, Dorothy Tripp
core   +1 more source

Single‐Cell RNA Sequencing of Human Lung Tissues Reveals Metallothionein‐Positive T Cells as a Novel Potential Marker of Susceptibility to Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing of lung samples and flow cytometry of peripheral blood, we identified a novel T cell subset with high metallothionein (MT) expression. These MT‐high T cells suppress CD8+ T cell cytotoxicity and are progressively depleted from healthy controls to chronic obstructive pulmonary disease (COPD) patients, positioning them as
Zengqing Liu, Xiaoxia Ren, Mi Mu, Huanyu Long, Jialu Lv, Zhihong Feng, Jie Liu, Jiajia Wang, Hui Deng, Fanyu Shi, Muzhi Zhang, Ruoyang Zhang, Yang Liu, Mengyu Xu, Yang Fan, Zengtao Wang, Zhe Lv, Yan Chen, Chris J. Corrigan, Ying Sun, Yahong Chen, Chen Chen, Ye Cui, Wei Wang   +23 more
wiley   +1 more source

NEW ATTRACTION MECHANISM OF INVESTMENT RESOURCES FOR FINANCING INFRASTRUCTURE PROJECTS

Наука и техника, 2013
The paper analyzes revenue-yielding bonds as an efficient tool of governmental and municipal management. Conditions required for issue of  security papers have considered in the paper.
A. S. Popkova
doaj  

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source

Shades of green: Unveiling the impact of municipal green bonds on the environment

Franklin Open
Green bonds allocate proceeds towards environmentally beneficial projects and sustainable development goals, distinguishing themselves from traditional bonds primarily in the use of proceeds determination.
Marta Campi, Gareth W. Peters, Kylie-Anne Richards   +2 more
doaj   +1 more source