Results 111 to 120 of about 1,558,394 (297)

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Lactobacillus‐Loaded Bioadhesive Hydrogel with Prolonged Retention and Microenvironmental Remodeling for Endometrial Repair and Fertility Restoration

Advanced Science, EarlyView.
A bioactive adhesive hydrogel capable of long‐term uterine retention (>14 days) and local microenvironment modulation is developed by straightforward integration of α‐lipoic acid, L‐arginine, tannic acid, and Lactobacillus johnsonii, which can markedly enhance endometrial repair and restore fertility in a rat model of endometrial injury.
Lifa Chen, Hui Zhou, Yifei Li, Yi Liang, Yifan Zhang, Huiyu Huang, Qiuxian Xie, Youchen Tang, Huixia Ye, Yu Zhang   +9 more
wiley   +1 more source

The Creation and Benchmarking of a Green Municipal Bond Index [PDF]

, 2018
As the green bond market grows, many are wondering if there is a pricing difference between green bonds and conventional bonds. In order to explore these ideas, we created bond indices specific to the green-labelled and climate-aligned municipal bond ...
Partridge, C, Medda, F
core   +1 more source

Analyzing OSHA Construction Accident Reports Using BERTopic Topic Modeling for Thematic Insights

Buildings
Hazards at construction sites can lead to severe accidents, posing significant risks to worker safety, financial stability, and public confidence in industry safety standards.
Yuntao Cao, Ziyi Qu, Shujie Wu, Yuting Chen, Martin Skitmore, Xingguan Ma, Jun Wang   +6 more
doaj   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

Strengthening Resilience: Social Responsibility and Citizen Participation in Local Governance

Administrative Sciences
The concept of resilience has gained significant prominence across various disciplines, particularly in the context of regional development. Specifically, the Social Responsibility of Local Public Administrations (SRLPA) may play a significant role in ...
María Isabel Sánchez-Hernández
doaj   +1 more source

The capitalization of taxes in bond prices: Evidence from the market for Government of Canada bonds [PDF]

This paper provides estimates of the extent to which corporate and personal income taxes are capitalized in bond prices. The methodology yields estimates of the degree of tax capitalization, rather than an implied tax rate.
Stuart Landon
core  

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Replication Archive for: Conflicts of Interest in Municipal Bond Advising and Underwriting

Code and pseudo-data for Conflicts of Interest in Municipal Bond Advising and ...
Garrett, Daniel
core   +2 more sources

Minimizing the Communication Gap Between Citizens and Municipal Authorities: An AI-Based Case Study in Cana a Dos Carajás, Brazil

IEEE Access
The accelerated growth of urbanization imposes increasing challenges on public management, demanding innovative solutions to optimize urban services and strengthen the bond between citizens and municipal authorities.
Vitor Hugo Macedo Gomes, Pedro Bacelar Moreira, Gustavo Henrique Broechl Moreno, Hugo Pereira Kuribayashi, Marcela Alves De Souza, Evelin Helena Cardoso Gomes, Jasmine Priscyla Leite De Araujo, Nandamudi Lankalapalli Vijaykumar, Marcelino Silva Da Silva, Joao Crisostomo Weyl Albuquerque Costa, Carlos Renato Lisboa Frances   +10 more
doaj   +1 more source