Results 211 to 220 of about 1,558,394 (297)

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source

Ultrasound-Assisted Ternary Deep Eutectic Solvent Extraction of Total Flavonoids from <i>Artemisia argyi</i>: GA-ANN Optimization, Greenness Assessment, and In Vitro Bioactivity Evaluation. [PDF]

Antioxidants (Basel)
Zhang X, Long J, Wang Z, Zhang Y, Yang T, Jiang Y, Wu F, Zhang X, Nie X, Wang G, Liu S.   +10 more
europepmc   +1 more source

Targeted‐Penetrating Biomimetic Hybrid Transfersomes for Enhanced Transdermal Gene Transfection in Hypertrophic Scar Therapy

Advanced Science, EarlyView.
Hypertrophic scar fibroblasts membrane‐hybridized cationic transfersomes enable efficient loading and transdermal delivery of TGF‐β1 siRNA through multiple skin penetration pathways. The biomimetic platform enhances homotypic targeting, transfection, and immune evasion, suppresses TGF‐β1‐driven fibrotic signaling, and reduces extracellular matrix ...
Hui Xing, Ziyi Zhao, Yuhui Yang, Yichen Lin, Yinglin Xuan, Ziyang Wang, Kai Lv, Xiaoxu Zhu, Zhi Zhang, Dong Ma   +9 more
wiley   +1 more source

Tandyukisins K-P, New Decalin Polyketides from <i>Trichoderma longicollum</i> 17007 with Antitubercular Activity Against <i>Mycobacterium tuberculosis</i> H37Ra. [PDF]

Antibiotics (Basel)
Yu J, Ning S, Di Y, Feng H, Li X, Wang K, Wang R, Ma M, Pan S, Jiang C, Jiang Y, Hsiang T, Chen J, Zhang W, Zhang L, Liu X, Zhang X, Zhu G.   +17 more
europepmc   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Electron-rich dianion vacancies boost diazenide intermediates for efficient chemical looping ammonia synthesis. [PDF]

Nat Commun
Wang J, Dai B, Li Z, Li J, Lu X, Li WQ, Jiang R, Qian K, Zheng S, Liu S, Kitano M, Hosono H, Lu Y, Chen JS, Ye TN.   +14 more
europepmc   +1 more source

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

Kissing Bond Damage Identification and Evaluation in CFRP-Reinforced Steel Plates Using Mixed-Frequency Ultrasonic Guided Waves. [PDF]

Sensors (Basel)
Guan R, Li H, Ni W, Huang T, Wang K, Han X.   +5 more
europepmc   +1 more source

Hydrogel Phase Transition‐Driven Soft Gating Circumvents Debye Screening for Advanced Biosensing

Advanced Science, EarlyView.
A 3D soft gate utilizes a macroscopic hydrogel phase transition to effectively circumvent Debye screening in high‐salt environments. The intact matrix maximizes transmembrane ion flux via volumetric Donnan enrichment and superhydrophilicity. Target‐triggered network disassembly abolishes these effects, introducing a synergistic physical barrier.
Liu Shi, Zimeng Zhang, Bingheng Li, Yalei Gao, Ruirui Zhang, Zheying Mu, Jian Ni, Bing Bo, Genxi Li   +8 more
wiley   +1 more source

Electron-Switching Astaxanthin Enables Programmable Triple-Phase Interface Chemistry for High-Loading All-Solid-State Lithium-Sulfur Batteries. [PDF]

Angew Chem Int Ed Engl
Chen Z, Liu H, Yan Y, Mei Y, Zhang B, Xiao K, Cai D, Chen C, Yang S, Yang Z.   +9 more
europepmc   +1 more source