Results 61 to 70 of about 13,154 (265)

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye   +9 more
wiley   +1 more source

Liquidity and volatility in the municipal bond market: Evidence from the municipal liquidity facility and other early interventions

open access: yesInternational Review of Economics & Finance
At the onset of the pandemic, the federal government stepped in with fiscal and monetary policy actions to assist distressed municipalities. In particular, the Municipal Liquidity Facility (MLF) was established to act as lender of last resort.
Felipe Lozano-Rojas, Luis Navarro
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

open access: yesAdvanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He   +10 more
wiley   +1 more source

Descentralização e endividamento municipal: formas, limites e possibilidades

open access: yesNova Economia, 2009
The objective of this article is to discuss alternatives to finance investments by municipalities. In general, current revenues are insufficient to finance large investments, what brings about the necessity of municipal indebtedness.
Amaury Patrick Gremaud   +1 more
doaj  

Forecasting Fatal Construction Accidents Using an STL–BiGRU Hybrid Framework: A Multi-Scale Time Series Approach

open access: yesBuildings
Accurate forecasting of fatal construction accidents is critical for proactive safety management; however, accident time series exhibit strong non-stationarity, nonlinear dynamics, and multi-scale temporal patterns that challenge conventional models ...
Yuntao Cao   +5 more
doaj   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

open access: yesAdvanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang   +11 more
wiley   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

open access: yesAdvanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan   +24 more
wiley   +1 more source

Oral Motion‐Powered Smart Dental Implant Abutment for In Situ Antibacterial and Cell Adhesion Through Piezoelectric Effect

open access: yesAdvanced Science, EarlyView.
We proposed a method based on the piezoelectric effect and fabricated an implant abutment on the basis of piezoelectric ceramic. Under physiological occlusal pressure, the oral motion‐powered smart dental implant abutments interacted with water and oxygen, promoting the formation of reactive oxygen species and achieving a synergistic and highly ...
Xiyu Shi   +15 more
wiley   +1 more source

Municipal bonds

open access: yesFinancijska praksa, 1995
U procesu transformacije Hrvatske u suvremeni tržišni sustav od posebne je važnosti reforma financijskog sektora. U radu se objašnjava bit i značaj municipalnih obveznica koje u razvijenim zemljama predstavljaju ključan instrument dugoročnog financiranja jedinica lokalne uprave i samouprave.
openaire   +1 more source

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