Advanced Science, EarlyView.This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu +14 more
wiley +1 more source
Dopant-free stabilization of ruthenium oxide <i>via</i> metallic Ru-induced d-orbital modulation for acidic water electrolysis. [PDF]
Chem SciTan L +11 more
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao +14 more
wiley +1 more source
Chemical analysis of extracellular vesicles by synchrotron-based X-ray imaging and scattering techniques: a review and perspective. [PDF]
Front Bioeng BiotechnolHuang L, Chen Y, Guo X, Zhou L.
europepmc +1 more source
A Wireless, Battery‐Free Artificial Throat Patch with Deep Learning for Emotional Speech Recognition
Advanced Science, EarlyView.In this work, Xu and co‐workers develop a wireless, battery‐free artificial throat patch system (ATPS) consisting of a carbon nanotube‐based thin‐film strain sensor and a miniaturized flexible printed circuit board, to enable real‐time sensing of throat signals.
Bingxin Xu +10 more
wiley +1 more source
Exploring the toxicological impact of DEHP exposure on colorectal cancer through network toxicology, machine learning and bioinformatics analysis. [PDF]
BMC Pharmacol ToxicolWang L, Qin Y, Fan W.
europepmc +1 more source
Advanced Science, EarlyView.SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding +10 more
wiley +1 more source
Clinical Dietitians' Perspectives on Nutritional Management in Children's Palliative Care: A Qualitative Study. [PDF]
J Hum Nutr DietTrae G, Winger A, Nordstrøm M.
europepmc +1 more source
Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing
Advanced Science, EarlyView.CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen +15 more
wiley +1 more source
Development of Cu@Zr-MOFs-PAN Nanofiber Composites for Efficient Methylene Blue Adsorption in Wastewater Treatment. [PDF]
Polymers (Basel)Li Z, Zhang L, Yuan G.
europepmc +1 more source