Results 101 to 110 of about 1,655,459 (311)
Advanced Science, EarlyView.Paeoniflorin allosterically targets the STING cyclic dinucleotide‐binding domain, stabilizes an inactive open conformation, and disrupts STING–OGT interaction to reduce Thr229 O‐GlcNAcylation and downstream signaling. This mechanism restrains myeloid STING activation, alleviates psoriasis‐like inflammation, and is supported by analyses of patient ...
Fang‐Fang Zhuo +10 more
wiley +1 more source
Historia. Instituciones. Documentos, 2007 This paper studies various features of the organisation of the town of Arnedo and its villages during the final years of the 15th century and the initial decades of the 16th century.
Francisco Javier Goicolea Julián
doaj
, 2021 This entry has been realised in the framework of the H2020-MSCA-RISE-2018 project “LoGov - Local Government and the Changing Urban-Rural Interplay”. LoGov aims to provide solutions for local governments that address the fundamental challenges resulting from urbanisation.
openaire +2 more sources
The Efficiency of States and Cities: Is There a Case for Public Land Leasing and Sales to Finance India.s Cities? [PDF]
In this study an attempt has been made to assess the potential of land as a municipal financing tool in four Indian cities, to enable better public service delivery and attainment of the MDGs. The institutional arrangements for land use are fragmented in
Sridhar, Kala Seetharam
core
Enriched Soil Organic Carbon Underpins Long‐Term Stable Crop Productivity Across China's Croplands
Advanced Science, EarlyView.Quantifying the nonlinear relationships and causal effects of soil organic carbon (SOC) on crop stability reveals specific critical thresholds and saturation points. This partitions the national SOC spectrum into three functional phases. Integrating these spatial delineations with high‐resolution maps of marginal gains pinpoints regions with the ...
Yuyang Huang +11 more
wiley +1 more source
Frontiers in Sustainable CitiesIntroductionUrban land governance in India is historically constrained by the lack of comprehensive, legally recognised, and spatially accurate land and property records.
Kunal Satyarthi +3 more
doaj +1 more source
Advanced Science, EarlyView.X‐shaped DNA promotes multivalent cGAS assembly and enhances cGAS‐STING signaling. When conjugated with antigenic peptides, the resulting X‐DNA‐based peptide vaccine promotes dendritic cell activation, antigen presentation, and antitumor T‐cell responses.
Jiabei Li +7 more
wiley +1 more source
Does Broader-Based Local Government affect Expenditure on Public Long-Term Care Insurance? The Case of Japan [PDF]
This paper considers the possible effects of broader-based local government, especially extended associations, in Japanese local public finance. We mainly analyze scale effects in public long-term care insurance expenditure, with our results indicating a
Hideo Yunoue, Haruaki Hirota
core
Advanced Science, EarlyView.Our study identifies MAGI3 as an intestinal epithelial gatekeeper that restrains inflammation‐associated colorectal tumorigenesis but is itself suppressed under highly inflammatory conditions. MAGI3 deficiency activates the STAT3‐CCL2 signaling, thereby promoting TAM‐mediated immunosuppression and inflammation‐associated colorectal tumor progression ...
Yumeng Yang +12 more
wiley +1 more source
Urban infrastructure finance from private operators : what have we learned from recent experience ? [PDF]
The author examines the role of private participation in infrastructure (PPI) in mobilizing finance for key urban services, that is, urban roads, municipal solid waste management, and water and sanitation since the early 1990s when private participation ...
Annez, Patricia Clarke
core