Results 51 to 60 of about 104,760 (309)
The Grahamstown city hall - the tale of two foundation stones
ContreeMunicipal government was introduced into Grahamstown in 1837. It was almost fifteen years later, however, before the first serious attempts were made to acquire a city hall and offices for the Municipal Commissioners, although an unsuccessful plan to buy
K.S. Hunt
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Advanced Science, EarlyView.ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang +11 more
wiley +1 more source
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
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Metropolitan municipal government for greater Cape Town
, 1982 Includes bibliographical references (leaves 480-496).The idea of this thesis was conceived as a result of experiences with the deprived areas of Greater cape Town.
Craythorne, D L
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GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Functional brain network mechanism of executive control dysfunction in temporal lobe epilepsy
BMC Neurology, 2020 Background Executive control dysfunction is observed in a sizable number of patients with temporal lobe epilepsy (TLE). Neural oscillations in the theta band are increasingly recognized as having a crucial role in executive control network.
Yanping Ren +5 more
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A survey of the borough governments of Bethlehem and South Bethlehem, Pa.
, 1917 This survery, provided by the Bureau of Municipal Research in New York City, examines the current state of affairs in the boroughs of Bethlehem and South Bethlehem, as well as provides recommendations on how the boroughs should be organized. The boroughs
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Advanced Science, EarlyView.This study employs a nanochain engineering approach combined with an in situ oxidation strategy to fabricate self‐insulating iron‐based magnetic nanochains, addressing the challenge of balancing magnetic coupling and electrical insulation in soft magnetic materials.
Dingrong Zuo +8 more
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LEGAL BASES OF MUNICIPAL GOVERNMENT IN RUSSIA AT THE VERGE OF XVIII-XIX cc.
Russian Journal of Economics and Law, 2008 The article is dedicated to the analysis of administrative-legal bases of the municipal government reorganization in Russia at the verge of XVIII-XIX cc. Viewing the largest administrative-legal acts of Paul I reign, dedicated to the municipal government
L. Kuanchaleyeva
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How “Rational” Is Urban Public Corruption?
Urban ScienceThis article reviews the literature on both (a) the general theory of public corruption and its evolution over time; and (b) the history of urban public corruption during the modern period into the present. In addition, this article conducts a historical
Cameron Elliott Gordon
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