Results 161 to 170 of about 1,837 (256)

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

A cross-sectional study of secondhand tobacco exposures and attitudes towards Senate Bill 793 in Latino mothers and middle and high school students in the San Francisco Bay Area. [PDF]

Tob Induc Dis
Michel K, Wojcicki JM.
europepmc   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

"Covering For Our City Blight": Kudzu and Public Health in Atlanta, 1979-1994. [PDF]

J Hist Med Allied Sci
Reilly K.
europepmc   +1 more source

Tailored D‐π Conjugation Boosts Piezocatalytic CO2 Reduction in a Platinum(II)‐Acetylide Framework

Advanced Science, EarlyView.
The highly conjugated metalII‐acetylide framework demonstrates efficient ultrasound‐driven conversion of CO2 to CO. The piezoelectric field generated by ultrasound facilitates electron transfer from the tetraphenylene π‐column to the MII‐bis(acetylide) moiety, enabling CO2 activation. Compared to PdII‐ and NiII‐based analogues, the stronger d–π orbital
Mude Zhu, Yingtang Zhou, Kai Wang, Xiaoyun Fan, Yang Ding, Wai‐Yeung Wong, Linli Xu   +6 more
wiley   +1 more source

Associations between Local and State Structural Stigma, Minority stress, and Mental Health in a Nationwide Sample of Sexual Minority Adolescents. [PDF]

Child Adolesc Social Work J
O'Brien RP, Blosnich JR, Cederbaum JA, Ferguson L, Hurlburt M, Traube DE, Parra LA, Rhoades H, Schrager SM, Goldbach JT.   +9 more
europepmc   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Land Use and Municipality Regulations. Study on the Functions of Delegatory Ordinances and Voluntary Ordinances.

JOURNAL OF RURAL PLANNING ASSOCIATION, 2001
openaire   +3 more sources

From Crisis to Action: Psychiatry's Ethical Imperative to Defend Transgender People's Rights, Dignity, and Access to Care. [PDF]

Am J Psychiatry
Breslow AS, Restar A, Cavic E, Alpert JE, Lê Cook B.   +4 more
europepmc   +1 more source

Extreme‐Thickness Meta‐Membrane for Controlling Terahertz Vectorial Beams

Advanced Science, EarlyView.
We propose ultra‐thin (λ/30) transmissive terahertz metasurfaces combining near‐field resonant and detour phases in coupled‐slit meta‐atoms, enabling continuous phase and polarization control beyond conventional designs. Based on leaky‐mode theory, scalar and vectorial terahertz Bessel beams at 0.39 THz are experimentally demonstrated, with ...
Yufei Song, Yixiang Xu, Yikai Xu, Yuanxi Liu, Shaojie Ma, Qiong He, Zhuo Wang, Lei Zhou   +7 more
wiley   +1 more source