Results 161 to 170 of about 480,840 (327)

Evaluation of the Implementation of Urban and Rural Local Government Unit (LGU) Responses to the COVID-19 Pandemic in Selected Communities in Luzon. [PDF]

Acta Med Philipp
Gundran CPD, Herbosa TJ, Lagmay AMFA, Faraon EJA, Cuaresma GA, Tubera-Panes D, Alejandro AC, Moltio MC, Caoeng GJB, Aparri JMZ, Forneloza DM.   +10 more
europepmc   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Connection, confluence and convergence: a protocol for reviewing policies on antimicrobial resistance and plastic pollution. [PDF]

BMJ Open
Shah-Rohlfs R, Landicho J, Endoma V, Sornillo BJ, Treskova M, Rocklöv J, McMahon SA, Reñosa MDC.   +7 more
europepmc   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

State and Local Responses to Climate Change through Hazard Adaptation Measures: White Paper Synthesizing Innovative State and Local Climate Change Adaptation Strategies [PDF]

, 2012
Marine Affairs Institute, Roger Williams University School of Law
core   +1 more source

Emissions Disclosures and Energy Use Reporting by Hospitals in the United States. [PDF]

NAM Perspect
Abel A, McCannon J, Boyden H, Keroack J, Lichter K, Bole A, Balbus J.   +6 more
europepmc   +1 more source

Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease

Advanced Science, EarlyView.
This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang, Yuting Liu, Shufan Jiang, Zilin Fang, Mengda Jiang, Xiaofeng Tao, Tianyi Zhu, Jipeng Li, Sijie Fang, Xuefei Song, Yinwei Li, Jing Sun, Chuanjun Tong, Zhengrun Gao, Huifang Zhou, Xianqun Fan   +15 more
wiley   +1 more source

Territorial Constraints on Trap-Neuter-Return in Insular Landscapes: Demographic and Ecological Implications of a Conservation-Oriented Policy. [PDF]

Animals (Basel)
Manzanares-Fernández R, Martínez-Campo J, Travieso-Aja MDM, Luzardo OP.   +3 more
europepmc   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Addressing Precarious Work Through Policy and Systems Change: A Case of a Local Health Department, University, and Worker Center Collaboration in Suburban Cook County, IL. [PDF]

J Public Health Manag Pract
Jarpe-Ratner E, Fisher L, Bonney T, Pinsker E, Kader A, Bell T, Rodriguez C, Barnett GM, Rubin R, Welter C.   +9 more
europepmc   +1 more source