Results 191 to 200 of about 664,031 (315)

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Too young to die: social inequalities and infant mortality in marginalized Roma communities in Slovakia. [PDF]

Popul Health Metr
Šprocha B, Bleha B.
europepmc   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Optimizing Territorial Healthcare Networks with a Capacity-Constrained Hub-And-Spoke Allocation Algorithm: The Province of L'Aquila Case Study. [PDF]

Healthcare (Basel)
Trebbi E, Barlattani T, Bologna A, Tognaccini L, Sili A, Di Martino G, Stan C, Odio C, Staniscia T, Pacitti F, Romano F.   +10 more
europepmc   +1 more source

Premio municipal

Atenea (Concepción), 1940
openaire   +1 more source

Municipal [PDF]

American Political Science Review, 1906
openaire   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Oropouche virus outbreaks in northeast Brazil between 2024-25 are characterized by sustained transmission and spread to newly affected areas. [PDF]

PLoS Negl Trop Dis
Melo ES, Silva SMDD, Lima GB, Silva AD, Silva AFD, Silva VGD, Azevedo EAN, Rother LW, Silva KMPE, Falcão DA, Vasconcelos AP, Costa MMOMD, Bezerra EAD, Carneiro TFO, Paiva EML, Oliveira JC, Bezerra MF, Paiva MHS, Acioli-Santos B, Morais CNL, Campos TL, Wallau GDL.   +21 more
europepmc   +1 more source

Species Dependent Toxicity Comparison Outcome

Advanced Science, EarlyView.
By quantitatively assessing and comparing toxicity responses across different animal species and material compositions, our data reveal that toxicity rankings among different materials may be reversed across species. ABSTRACT Toxicity comparison plays a crucial role in material selection across diverse application fields.
Lian Xiao, Zhan Yu, Sihang Liu, Yuheng Liu, Chong Deng, Yugang Zhao, Yi Huang, Zhi‐Gang Zheng   +7 more
wiley   +1 more source

Diversity, Host Attachment Preferences and Role of Tick Rhipicephalus microplus in the Transmission of Bartonella spp. and Rickettsia spp. in Cattle From Southern Benin. [PDF]

Vet Med Sci
Ahouandjinou MJ, Affolabi ZK, Hougbe SZ, Koumodji KD, Agboho PA, Koukpo ZC, Fassinou AJ, Chitou S, Towakinou L, Tokponnon F, Akogbeto M, Ossè RA.   +11 more
europepmc   +1 more source