Results 121 to 130 of about 381,974 (215)
Advanced Science, EarlyView.Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie +10 more
wiley +1 more source
Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy
Advanced Science, EarlyView.By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng +16 more
wiley +1 more source
F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers
Advanced Science, EarlyView.Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu +5 more
wiley +1 more source
NRS-18538 | Postal Payments Register [Hurstville Municipality]
This series comprises a Postal Payments Register for the Hurstville ...
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Information in connection with the Municipality of Stellenbosch vol. 1, no. 10, 1960-04-29
, 1960 ims_1960-04-29.pdf derived from archival TIFF file. Digital copies were created from the original hard copy collection of the newsletter held by Stellenbosch Library and Information Service Africana Collection.IMS (Information in connection with the ...
Dempsey, W. C.
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VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
Sutureless Cataract Surgery without Phacoemulsification
Journal of Nepal Medical Association, 2003 S P Dhital +4 more
doaj +1 more source
Information in connection with the Municipality of Stellenbosch vol. 1, no. 44, 1963-08-23
, 1963 ims_1963-08-23.pdf derived from archival TIFF file. Digital copies were created from the original hard copy collection of the newsletter held by Stellenbosch Library and Information Service Africana Collection.IMS (Information in connection with the ...
Dempsey, W. C.
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Advanced Science, EarlyView.In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun +15 more
wiley +1 more source
NRS-16799 | Finance Committee Minute Books [Municipality of Annandale]
<p>This series comprises Finance Committee Minute Books of the Municipality of Annandale. Volumes containing handwritten, signed minutes of meetings of the Municipality’s Finance Committee.
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