Results 21 to 30 of about 381,974 (215)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Cave development in the Qatar peninsula: insights on their origin and associated geohazards

Acta Carsologica
The geology of the State of Qatar comprises large spans of carbonate rocks at the surface and evaporitic rocks at shallow depth, and a number karst features (depressions, caves) spread across the country that may cause challenges during land development ...
Jerome Perrin, Renaud Couëffé, Bastien Lemaire, Clement Lerevenu, Richeshkumar Pillai, Cecile Allanic, Silvain Yart, Melisende Métais Bossard, Alexandre Ortiz, Oliver Higgins, Florian Masson, Boris Matti, Gildas Noury, Elalim Ahmed, Umi Salmah Samad, Sayed Bukhari, Salem Al-Yafei   +16 more
doaj   +1 more source

Long‐term usage patterns and clinical outcomes in a community‐based differentiated antiretroviral therapy delivery programme in South Africa

Journal of the International AIDS Society, 2023
Introduction There is little data on long‐term implementation and outcomes for people living with HIV (PLHIV) in differentiated antiretroviral therapy (ART) delivery programmes. We aimed to analyse usage patterns of and associated treatment outcomes in a
Lara Lewis, Yukteshwar Sookrajh, Johan van derMolen, Thokozani Khubone, Munthra Maraj, Phelelani Sosibo, Rose vanHeerden, Francesca Little, Reshma Kassanjee, Nigel Garrett, Jienchi Dorward   +10 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Medical Students’ Experience: Community Engagement and Advocacy through Photovoice

International Journal of Medical Students, 2016
NA
Heather Charlotte Hunter, Deep Jaiswal, Brittany Cameron, Matthew J. To, Suzanne Kathleen Clarke, Catherine Cox, Ciaran Lane, Cinera States   +7 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Spontaneous healing of hypertrophic pseudoarthrosis of pediatric mid shaft ulna with elastic stable intramedullary nailing in situ: A case report

SAGE Open Medical Case Reports
Forearm fractures are the most common type of fractures in pediatric age. As children have excellent healing potential, fracture nonunion is a very uncommon complication.
Ashbin Bhattarai, Dipendra Subedi, Jyotsna Bhandari, Sushan Homagain, Suruchi Paudel, Jeevan Ghimire   +5 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Prediction of body weight using body measurements in some sheep and goats in Qatar

Journal of Applied Animal Research
The study aimed to identify the relationship between body measurements and the weight of sheep and goats. A total of 324 heads of sheep and 261 heads of goats were used.
Muzzamil Atta, Abu-baker S. Ali, Mutasim B. Mohamed, Huda M. Al-Dosari, Hamad S. Al-Shamari   +4 more
doaj   +1 more source