Results 241 to 250 of about 176,477 (315)

Intensive management negatively impacts field margin ecosystem service indicators at both field and landscape levels. [PDF]

Ecol Appl
Genty L, Meynard CN, Bopp MC, Henckel L, Chayre A, Gibert C, Fried G.   +6 more
europepmc   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Economic implications of the different statin prescribing patterns in Central Portugal: a longitudinal analysis. [PDF]

J Pharm Policy Pract
Abrantes C, Negrão LG, Coelho C, Castel-Branco MM, Figueiredo IV, Fernandez-Llimos F.   +5 more
europepmc   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Zooming In: Assessing the Transferability of SDMs From Large to Small Spatial Extents. [PDF]

Ecol Evol
Seuren JRG, Droog MCE, Hilbers JP, Schipper AM.   +3 more
europepmc   +1 more source

A Machine Learning‐Driven Pore‐Scale Network Model Coupling Reaction Kinetics and Interparticle Transport for Catalytic Process Design

Advanced Science, EarlyView.
Designing catalytic processes in porous reactors requires resolving coupled multiscale reaction–transport phenomena. We develop a machine‐learning‐accelerated pore‐scale dual‐network model with kinetics (DNMK), which captures reaction kinetics, pore‐scale transport, and reactor‐level behavior.
Ming‐Liang Qu, Zhao‐Bin Ding, Dingyue Zhang, Sajjad Foroughi, Huanhao Chen, Zi‐Tao Yu, Jiyizhe Zhang, Lifeng Xiao, Martin J. Blunt, Xiaolei Fan, Qingyang Lin   +10 more
wiley   +1 more source

Patient flow and safety after implementing a community paramedicine service: a quasi-experimental study. [PDF]

BMJ Open
Elden OE, Brulin E, Uleberg O, Landstad BJ, Dalen H.   +4 more
europepmc   +1 more source

Analysis of Heavy Precipitation in the Adigeni and Chokhatauri Municipalities on July 21, 2025 Based on Satellite Measurements [PDF]

Beglarashvili, N., Elizbarashvili, I., Jamrishvili, N., Janelidze, I., Pipia, M., Tavidashvili, Kh.   +5 more
openalex  

Behavior‐ and Cell Type‐Specific Cortico‐Striatal Decoupling in a Parkinson's Disease‐Like Mouse Model

Advanced Science, EarlyView.
Utilizing dual‐site fiber photometry, this study examines cortico‐striatal coupling with cell type resolution, identifying behavior‐ and cell type‐specific cortico striatal decoupling and its dopamine‐dependent mechanism in a Parkinson's disease mouse model.
Xu‐Ran Yao, Yang Liu, Wei‐Tong Zheng, Mao‐Qing Huang, Kai‐Wen He   +4 more
wiley   +1 more source

Prevalence of malaria infection and associated factors among children under five years attending health facilities in the Nandom Municipality, Upper West Region, Ghana. [PDF]

Malar J
Boadu S, Azornu CK, Axame W, Bonsu EO, Wumnaya R, Yidana S, Abanga WA, Sarpomaa Asante L, Adjei MR, Kubio C.   +9 more
europepmc   +1 more source