Results 141 to 150 of about 131,162 (265)

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Mortality and morbidity caused by pneumonia in children and adolescents are associated with socioeconomic and urban conditions in São Paulo, Brazil. [PDF]

Rev Paul Pediatr
Cabral-Miranda W, Lamas CA, Beloni C, Samos KRA, Fernandes FR, Wandalsen GF.   +5 more
europepmc   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

166 How can municipalities build lasting clinical observation competence? KlinObsKommune explained: the what, the how, and the life-saving why’

BMJ Open Quality
Åste Renolen, Heidi Synnøve Isberg, Mette Sophie Klev   +2 more
doaj   +1 more source

Species- and Processing-Dependent Variability of Ascorbic Acid in Fruits of 14 <i>Rosa</i> Species and its Redox Behavior toward Iron and Copper Ions. [PDF]

ACS Omega
Raal A, Meos A, Ainsaar I, Movtšanjuk O, Remmelgas KL, Koshovyi O, Lomozová Z, Harčárová P, Mladěnka P.   +8 more
europepmc   +1 more source

Tailored D‐π Conjugation Boosts Piezocatalytic CO2 Reduction in a Platinum(II)‐Acetylide Framework

Advanced Science, EarlyView.
The highly conjugated metalII‐acetylide framework demonstrates efficient ultrasound‐driven conversion of CO2 to CO. The piezoelectric field generated by ultrasound facilitates electron transfer from the tetraphenylene π‐column to the MII‐bis(acetylide) moiety, enabling CO2 activation. Compared to PdII‐ and NiII‐based analogues, the stronger d–π orbital
Mude Zhu, Yingtang Zhou, Kai Wang, Xiaoyun Fan, Yang Ding, Wai‐Yeung Wong, Linli Xu   +6 more
wiley   +1 more source

First record of Rhodnius nasutus Stål, 1859 (Hemiptera: Reduviidae: Triatominae) in an urban residential environment in the municipality of Barra, Bahia. [PDF]

Rev Bras Parasitol Vet
Conceição MDS, Albuquerque MO, Almeida MO, Saraiva ADS, Pauda AD, Brito RL, Magalhães-Junior JT, Santos FD.   +7 more
europepmc   +1 more source

Premio municipal

Atenea (Concepción), 1940
openaire   +1 more source

A Folded, Structure‐Integrated Bimodal Sensor Enabling Non‐Contact and Tactile Perception for Intelligent Robots

Advanced Science, EarlyView.
A foldable bimodal sensor integrates a triboelectric nanogenerator and graphene piezoresistive effect into a monolithic laser‐induced graphene film. It enables synchronous non‐contact and tactile perception, achieving a distance of 110 mm, a sensitivity of 11.2 kPa−1, and a response time of 10 ms.
Weixiong Yang, Yuhan Guo, Mingguang Han, Bin Feng, Yuan Ma, Bingang Xu, Fu Liu, Dan Wang, Pingping Hao, Xilun Ding, Sida Luo   +10 more
wiley   +1 more source

Societal costs for the closest family relatives of patients with brain disorders in Denmark: a population-based cohort study. [PDF]

BMJ Public Health
Thomsen MK, Rasmussen TB, Olsen J, Skipper N, Stallknecht SB, Plana-Ripoll O, Christiansen CF.   +6 more
europepmc   +1 more source