Results 151 to 160 of about 250,477 (263)

PINCH proteins orchestrate vascular mural cell homeostasis through integrated signaling and transcriptional networks. [PDF]

open access: yesAngiogenesis
Wang C   +10 more
europepmc   +1 more source

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild‐Type Receptors: Identification of Highly Selective Inhibitors That Block the Process

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CADASIL is the major cause of early‐onset stroke and cognitive dysfunction, including dementia. It is caused by mutations in the NOTCH3 receptor that result in the formation of protein aggregates in the small vessel walls of the brain. We demonstrated that NOTCH3 CADASIL variant receptor aggregation is strictly dependent on interactions with NOTCH3 ...
Haijiang Wang   +9 more
wiley   +1 more source

Nominata | Reviwers Acknowledgements

open access: yesMural Internacional, 2022
Mural Internacional
doaj  

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, Volume 600, Issue 5, Page 591-611, March 2026.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Ring-like (Donut-Shaped) Intracranial Aneurysms: A Warning Morphology of Mural Jet Flow and Pre-Rupture Instability. [PDF]

open access: yesDiagnostics (Basel)
Nestorović D   +5 more
europepmc   +1 more source

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

open access: yesAdvanced Science, Volume 13, Issue 13, 3 March 2026.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng   +7 more
wiley   +1 more source

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

open access: yesAdvanced Science, Volume 13, Issue 13, 3 March 2026.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside   +11 more
wiley   +1 more source

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