Results 1 to 10 of about 13,727 (226)

Stabilization of Murine Norovirus by Bacteria [PDF]

mSphere, 2022
Enteric viruses encounter various bacteria in the host, which can impact infection outcomes. The interactions between noroviruses and enteric bacteria are not well understood.
Melissa R. Budicini, Julie K. Pfeiffer
doaj   +4 more sources

Production of infectious reporter murine norovirus by VP2 <i>trans</i>-complementation. [PDF]

J Virol, 2023
In this study, we revealed that some of the coding regions of ORF3 could be replaced by a foreign gene and infectious virus could be produced when VP2 was supplied. Propagation of this virus depended on VP2 being supplied in trans , indicating that this virus could infect only once.
Ishiyama R, Yoshida K, Oikawa K, Takai-Todaka R, Kato A, Kanamori K, Nakanishi A, Haga K, Katayama K.   +8 more
europepmc   +4 more sources

Experimental Adaptation of Murine Norovirus to Calcium Hydroxide. [PDF]

Front Microbiol, 2022
Slaked lime (calcium hydroxide) is a commonly used disinfectant for fecal sludge. Although viruses are inactivated by lime treatment, whether RNA viruses adapt to lime treatment has not yet been determined. Here, we show that murine norovirus developed higher tolerance during serial passages with lime treatment.
Oishi W, Sato M, Kubota K, Ishiyama R, Takai-Todaka R, Haga K, Katayama K, Sano D.   +7 more
europepmc   +5 more sources

Murine norovirus allosteric escape mutants mimic gut activation. [PDF]

J Virol
Murine norovirus (MNV) undergoes large conformational changes in response to the environment. The T=3 icosahedral capsid is composed of 180 copies of ~58 kDa VP1 that has N-terminal (N), shell (S) and C-terminal protruding (P) domains. In phosphate buffered saline, the P domains are loosely tethered to the shell and float ~15Å above the surface.
Sherman MB, Smith HQ, Cox F, Wobus CE, Lynch GC, Pettitt BM, Smith TJ.   +6 more
europepmc   +6 more sources

Virucidal activity of chlorine dioxide in combination with acetic acid or citric acid and a surfactant, in presence of interfering substances, against polio-, adeno- and murine norovirus in suspension-, carrier- and four-field tests [PDF]

GMS Hygiene and Infection Control
Introduction: The aim of the study was to investigate whether the virucidal effectiveness of chlorine dioxid against adenovirus and murine norovirus can be improved by combining it with carboxylic acids and surfactants.Method: The virucidal efficacy ...
Tarka, Patryk, Chruściel, Arkadiusz, Hreczuch, Wiesław, Kanecki, Krzysztof, Nitsch-Osuch, Aneta   +4 more
doaj   +4 more sources

Development of a replication competent murine norovirus reporter system. [PDF]

PLoS Pathog
Caliciviruses are significant agricultural and human pathogens that are poorly understood due to the dearth of molecular tools, including reporter systems. We report the development of a robust luciferase-based reporter system for a model calicivirus, murine norovirus (MNoV).
Olson MC, Pierce LR, Orchard RC.
europepmc   +7 more sources

Bacteria-mediated stabilization of murine norovirus [PDF]

, 2022
AbstractEnteric viruses encounter various bacteria in the host which can impact infection outcomes. The interactions between noroviruses and enteric bacteria are not well understood. Previous work determined that murine norovirus (MNV), a model norovirus, had decreased replication in antibiotic-treated mice compared with conventional mice.
Melissa R. Budicini, Julie K. Pfeiffer
openalex   +2 more sources

Bacterial extracellular vesicles control murine norovirus infection through modulation of antiviral immune responses [PDF]

Frontiers in Immunology, 2022
Human norovirus is the primary cause of non-bacterial gastroenteritis globally and is the second leading cause of diarrheal deaths in children in developing countries. However, effective therapeutics which prevent or clear norovirus infection are not yet
Sutonuka Bhar, Guanqi Zhao, Julia D. Bartel, Heather Sterchele, Alexa Del Mazo, Lisa E. Emerson, Mariola J. Edelmann, Melissa K. Jones   +7 more
doaj   +2 more sources

TRIM47 inhibits murine norovirus replication in a strain-dependent manner [PDF]

Journal of Virology
Human norovirus is the leading cause of gastroenteritis worldwide. Norovirus exhibits remarkable genetic diversity. Understanding the impact of genetic diversity on infection and immunity has been challenging due to the difficulties in in vitro ...
Stacey L. Crockett, Linley R. Pierce, Rachel Rodgers, Meagan Sullender, Lawrence A. Schriefer, Mridula Annaswamy Srinivas, Sanghyun Lee, Megan T. Baldridge, Robert C. Orchard   +8 more
doaj   +2 more sources

Structural Studies on the Shapeshifting Murine Norovirus. [PDF]

Viruses, 2021
Noroviruses are responsible for almost a fifth of all cases of gastroenteritis worldwide. The calicivirus capsid is composed of 180 copies of VP1 with a molecular weight of ~58 kDa. This coat protein is divided into the N-terminus (N), the shell (S) and C-terminal protruding (P) domains. The S domain forms a shell around the viral RNA genome, while the
Sherman MB, Williams AN, Smith HQ, Pettitt BM, Wobus CE, Smith TJ.   +5 more
europepmc   +5 more sources