Results 91 to 100 of about 13,538 (226)

Commensal Viruses Promote Intestinal Stem Cell Regeneration Following Radiation Damage by Inhibiting Hyperactivation of RIG‐I and Notch Signals

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Ionizing radiation disrupts gut virome and bacteriome. Gut commensal viruses protect against intestinal damage and promote stem cell regeneration by inhibiting hyperactivation of RIG‐I and Notch signaling in stem cells. Fecal virome transplantation (FVT) from healthy donors can serve as a potential therapeutic intervention by enriching phages targeting
Xiaotong Zhao, Yu Cai, Yujia Hou, Yanjin Wu, Tingting Wei, Lili Li, Zhaojun Duan, Xinran Lu, Jiahui Meng, Haitao Zhou, Qin Wang, Jinhan Wang, Chang Xu, Liqing Du, Saijun Fan, Feng Wang, Qiang Liu, Yang Liu   +17 more
wiley   +1 more source

Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo. [PDF]

, 2016
Intrahost genetic diversity and replication error rates are intricately linked to RNA virus pathogenesis, with alterations in viral polymerase fidelity typically leading to attenuation during infections in vivo.
Armando Arias, Dalan Bailey, Elsa Ghurburrun, Ian Goodfellow, Lucy Thorne, W. Paul Duprex   +5 more
core   +4 more sources

Recovery Optimization and Survival of the Human Norovirus Surrogates Feline Calicivirus and Murine Norovirus on Carpet [PDF]

Applied and Environmental Microbiology, 2017
ABSTRACT Carpets have been implicated in prolonged and reoccurring outbreaks of human noroviruses (HuNoV), the leading cause of acute gastroenteritis worldwide. Viral recovery from environmental surfaces, such as carpet, remains undeveloped.
Guohui Huang, Angela Fraser, David Buckley, Xiuping Jiang   +3 more
openaire   +3 more sources

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

iMeta, Volume 4, Issue 5, October 2025.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang, Bin Wang, Yong‐Le Yang, Jin‐Xin Meng, Meng‐Di Zhang, Yi‐Ke Li, Bo Dong, Yanan Zhang, Bo‐Wen Liu, Dong Yang, Chun‐Miao Ji, Yao‐Wei Huang, Shu Jeffrey Zhu   +12 more
wiley   +1 more source

Environmentally-triggered contraction of the norovirus virion determines diarrheagenic potential

Frontiers in Immunology, 2022
Noroviruses are the leading cause of severe childhood diarrhea and foodborne disease worldwide. While they are a major cause of disease in all age groups, infections in the very young can be quite severe with annual estimates of 50,000-200,000 fatalities
Emily W. Helm, Amy M. Peiper, Matthew Phillips, Caroline G. Williams, Michael B. Sherman, Theresa Kelley, Hong Q. Smith, Sorin O. Jacobs, Dhairya Shah, Sarah M. Tatum, Neha Iyer, Marco Grodzki, Joyce C. Morales Aparicio, Elizabeth A. Kennedy, Mikayla S. Manzi, Megan T. Baldridge, Thomas J. Smith, Stephanie M. Karst   +17 more
doaj   +1 more source

Diversity of murine norovirus strains isolated from asymptomatic mice of different genetic backgrounds within a single U.S. research institute.

PLoS ONE, 2011
Antibody prevalence studies in laboratory mice indicate that murine norovirus (MNV) infections are common, but the natural history of these viruses has not been fully established.
Elyssa L Barron, Stanislav V Sosnovtsev, Karin Bok, Victor Prikhodko, Carlos Sandoval-Jaime, Crystal R Rhodes, Kim Hasenkrug, Aaron B Carmody, Jerrold M Ward, Kathy Perdue, Kim Y Green   +10 more
doaj   +1 more source

Dissecting Microscopic Colitis Immunopathophysiology: Insights From Basic Research

United European Gastroenterology Journal, Volume 13, Issue 8, Page 1367-1378, October 2025.
ABSTRACT Microscopic colitis is an inflammatory bowel disease (IBD) comprising two clinically undiscernible entities: collagenous colitis and lymphocytic colitis. Collagenous colitis associates with HLA genes and displays a Th1/Tc1–Th17/Tc17 profile with pericryptal myofibroblast activity, water malabsorption and secondary fluid loss due to altered ...
Andreas Münch, Celia Escudero‐Hernández   +1 more
wiley   +1 more source

Differentiation and Protective Capacity of Virus-Specific CD8 [PDF]

, 2017
Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune dysfunction is unknown.
Bengsch, Bertram, Cosma, Gabriela L., Eisenlohr, Laurence C., Lau, Chi Wai, Manne, Sasikanth, Nice, Timothy J., Palko, Olesya, Pattekar, Ajinkya, Sun, Yuhang, Tacheva, Ralitza, Tomov, Vesselin T., Virgin, Herbert W., Wherry, E. John   +12 more
core   +1 more source

Analysis of Antibody Changes in Laboratory Mice Infected with Murine Norovirus

Shiyan dongwu yu bijiao yixue, 2021
ObjectiveTo study the changes of total IgG antibodies and neutralizing antibodies in KM, BALB/c, NIH, C57BL/6J and BALB/c-nu mice infected with murine norovirus (MNV).MethodsFive strains of KM, BALB/c, NIH, C57BL/6J and BALB/c-nu mice were collected ...
LI Xiaobo, FU Rui, WANG Shujing, LI Wei, WANG Shasha, HUANG Zongwen, QIN Xiao, WANG Ji, YUE Bingfei   +8 more
doaj   +1 more source

Seroconversion of 1-year-old Mice to Murine Norovirus [PDF]

Journal of the American Association for Laboratory Animal Science, 2019
Rodent sentinel screening for adventitious pathogens is an integral part of many biomedical research institutes and universities that use rodents in research. Typical screening programs involving live sentinel animals typically purchase young SPF sentinel animals that are sampled and replaced quarterly.
Zaias, Julia, Farrington, Catia, Livingston, Robert S, Waterman, Linda   +3 more
openaire   +4 more sources