NMR Experiments Shed New Light on Glycan Recognition by Human and Murine Norovirus Capsid Proteins [PDF]
Viruses, 2021 Glycan–protein interactions are highly specific yet transient, rendering glycans ideal recognition signals in a variety of biological processes. In human norovirus (HuNoV) infection, histo-blood group antigens (HBGAs) play an essential but poorly ...
Robert Creutznacher +9 more
doaj +3 more sources
Production of infectious reporter murine norovirus by VP2 <i>trans</i>-complementation. [PDF]
J Virol, 2023 Human norovirus (HuNoV) causes gastroenteritis, a disease with no effective therapy or vaccine, and does not grow well in culture. Murine norovirus (MNV) easily replicates in cell cultures and small animals and has often been used as a model to elucidate
Ishiyama R +8 more
europepmc +2 more sources
Infection of neonatal mice with the murine norovirus strain WU23 is a robust model to study norovirus pathogenesis. [PDF]
Lab Anim (NY), 2023 A mouse model to study norovirus pathogenesis is described. The murine norovirus strain WU23, originally isolated from an intestinal site, induces severe but self-resolving diarrhea in neonates, reflecting the pathology observed during human norovirus ...
Peiper AM +12 more
europepmc +2 more sources
Murine norovirus mutants adapted to replicate in human cells reveal a post-entry restriction. [PDF]
J VirolRNA viruses lack proofreading in their RNA polymerases and therefore exist as genetically diverse populations. By exposing these diverse viral populations to selective pressures, viruses with mutations that confer fitness advantages can be enriched.
Budicini MR +3 more
europepmc +3 more sources
VPg of murine norovirus binds translation initiation factors in infected cells [PDF]
Virology Journal, 2006 Background Norovirus genomic and subgenomic RNAs are covalently linked at the 5' nucleotide to a 15 kD protein called VPg. VPg of two human norovirus strains binds translation initiation factor eIF3 and other eIFs in vitro, suggesting VPg functions in ...
Wobus Christiane E +2 more
doaj +2 more sources
Exploring the Efficacy of Peptides and Mimics against Influenza A Virus, Adenovirus, and Murine Norovirus. [PDF]
Int J Mol SciThe ongoing battle against viral pandemics continues, with the possibility of future outbreaks. The search for effective antiviral compounds that can combat a diverse range of viruses continues to be a focal point of research. This study investigated the
Urmi UL +7 more
europepmc +2 more sources
Murine Norovirus Interaction with Enterobacter cloacae Leads to Changes in Membrane Stability and Packaging of Lipid and Metabolite Vesicle Content. [PDF]
Microbiol Spectr, 2023 Extracellular vesicles from commensal bacteria are recognized for their importance in modulating host immune responses, and vesicle content is related to their impact on the host.
Mosby CA, Edelmann MJ, Jones MK.
europepmc +2 more sources
Lipopolysaccharide Tolerance Enhances Murine Norovirus Reactivation: An Impact of Macrophages Mainly Evaluated by Proteomic Analysis. [PDF]
Int J Mol Sci, 2023 Because of endotoxemia during sepsis (a severe life-threatening infection), lipopolysaccharide (LPS) tolerance (the reduced responses to the repeated LPS stimulation) might be one of the causes of sepsis-induced immune exhaustion (the increased ...
Makjaroen J +5 more
europepmc +2 more sources
Genetic diversity of murine norovirus populations less susceptible to chlorine. [PDF]
Front MicrobiolHigh genetic diversity in RNA viruses contributes to their rapid adaptation to environmental stresses, including disinfection. Insufficient disinfection can occur because of the emergence of viruses that are less susceptible to disinfection.
Wanguyun AP +4 more
europepmc +2 more sources
Assessing the Removal Efficiency of Murine Norovirus 1, Hepatitis A Virus, and Human Coronavirus 229E on Dish Surfaces Through General Wash Program of Household Dishwasher. [PDF]
Food Environ Virol, 2023 The performance of dishwashers in removing live viruses is an important informative value in practical applications. Since foodborne viruses are present in contaminated food surfaces and water environments.
Wang Z +8 more
europepmc +2 more sources