Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro. [PDF]
, 2018 Human norovirus (HuNoV) is a major cause of nonbacterial gastroenteritis worldwide, yet despite its impact on society, vaccines and antivirals are currently lacking. A HuNoV replicon system has been widely applied to the evaluation of antiviral compounds
Emmott, Edward +4 more
core +1 more source
eLife, 2019 Knowledge of the host factors required for norovirus replication has been hindered by the challenges associated with culturing human noroviruses. We have combined proteomic analysis of the viral translation and replication complexes with a CRISPR screen,
Myra Hosmillo +14 more
doaj +1 more source
Correction: MDA-5 Recognition of a Murine Norovirus
PLoS Pathogens, 2008 The fifth author's name is displayed incorrectly in the by-line and in the article citation. The author's correct attribution is Herbert W. Virgin. The correct citation is: McCartney SA, Thackray LB, Gitlin L, Gilfillan S, Virgin HW, et al. (2008) MDA-5 Recognition of a Murine Norovirus. PLoS Pathog 4(7): e1000108.
Stephen A. McCartney +5 more
openaire +2 more sources
Potential of human norovirus surrogates and Salmonella enterica contamination of pre-harvest basil (Ocimum basilicum) via leaf surface and plant substrate [PDF]
, 2018 Fresh produce has been identified as an important vehicle for foodborne pathogen transmission and fresh culinary herbs have occasionally been associated with human pathogens and illness. In this study, the fate of human NoV surrogates [murine norovirus 1
Li, Dan, Uyttendaele, Mieke
core +1 more source
Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages.
PLoS Biology, 2004 Noroviruses are understudied because these important enteric pathogens have not been cultured to date. We found that the norovirus murine norovirus 1 (MNV-1) infects macrophage-like cells in vivo and replicates in cultured primary dendritic cells and ...
Christiane E Wobus +9 more
doaj +1 more source
Impact of pH and protein hydrophobicity on norovirus inactivation by heat-denatured lysozyme.
PLoS ONE, 2020 Norovirus, the leading cause of non-bacterial food poisoning, is responsible for several outbreaks associated with bivalves and ready-to-eat food products worldwide.
Michiko Takahashi +5 more
doaj +1 more source
Seroconversion of 1-year-old Mice to Murine Norovirus [PDF]
Journal of the American Association for Laboratory Animal Science, 2019 Rodent sentinel screening for adventitious pathogens is an integral part of many biomedical research institutes and universities that use rodents in research. Typical screening programs involving live sentinel animals typically purchase young SPF sentinel animals that are sampled and replaced quarterly.
Zaias, Julia +3 more
openaire +3 more sources
The murine norovirus core subgenomic RNA promoter consists of a stable stem-loop that can direct accurate initiation of RNA synthesis. [PDF]
, 2014 UNLABELLED: All members of the Caliciviridae family of viruses produce a subgenomic RNA during infection. The subgenomic RNA typically encodes only the major and minor capsid proteins, but in murine norovirus (MNV), the subgenomic RNA also encodes the ...
Bailey, Dalan +9 more
core +1 more source
VPg of murine norovirus binds translation initiation factors in infected cells
Virology Journal, 2006 Background Norovirus genomic and subgenomic RNAs are covalently linked at the 5' nucleotide to a 15 kD protein called VPg. VPg of two human norovirus strains binds translation initiation factor eIF3 and other eIFs in vitro, suggesting VPg functions in ...
Wobus Christiane E +2 more
doaj +1 more source
Human Intestinal Enteroids to Evaluate Human Norovirus GII.4 Inactivation by Aged-Green Tea
Frontiers in Microbiology, 2020 Human noroviruses are the leading cause of epidemic and sporadic acute gastroenteritis worldwide and the most common cause of foodborne illness in the United States.
Walter Randazzo +5 more
doaj +1 more source