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Allosteric Modulators of the M4 Muscarinic Acetylcholine Receptor [PDF]
ACS Medicinal Chemistry Letters, 2017 openaire +5 more sources
Role of muscarinic acetylcholine receptors on interleukin-2 formation in lymphocytes
, 2000 Yasunobu Okuma +4 more
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Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia.
American Journal of Psychiatry, 2022Schizophrenia remains a challenging disease to treat effectively with current antipsychotic medications due to their limited efficacy across the entire spectrum of core symptoms as well as their often burdensome side-effect profiles and poor tolerability.
S. Paul +4 more
semanticscholar +1 more source
Muscarinic acetylcholine receptor
Progress in Neurobiology, 1978ABSTRACT Muscarinic acetylcholine receptors from rat cerebral cortex and small intestine were studied by the high affinity and high specific activity antagonists 3 H-3-quinuclidinyl benzilate (3-QNB) (29.4 Ci/mmol) and 3 H-N-methyl-4-piperidinyl benzilate (4-NMPB) (55.4 Ci/mmol).
Edith Heilbronn, Tamas Bartfai
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Muscarinic Acetylcholine Receptors
Current Pharmaceutical Design, 2006Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate cascade leading to intracellular ...
Masaru Ishii, Yoshihisa Kurachi
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Antidepressants and the Muscarinic Acetylcholine Receptor
Archives of General Psychiatry, 1977Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones.
Solomon H. Snyder, Henry I. Yamamura
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The Muscarinic Acetylcholine Receptor M5: Therapeutic Implications and Allosteric Modulation.
ACS Chemical Neuroscience, 2018The muscarinic acetylcholine receptor (mAChR) subtype 5 (M5) was the most recent mAChR to be cloned and has since emerged as a potential therapeutic target for a number of indications.
Aaron M. Bender +2 more
semanticscholar +1 more source
ACS Chemical Neuroscience, 2018
Abnormal hippocampal activity has been linked to impaired cognitive performance in Alzheimer's disease and schizophrenia, leading to a hypothesis that normalization of this activity may be therapeutically beneficial.
M. Popiolek +8 more
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Abnormal hippocampal activity has been linked to impaired cognitive performance in Alzheimer's disease and schizophrenia, leading to a hypothesis that normalization of this activity may be therapeutically beneficial.
M. Popiolek +8 more
semanticscholar +1 more source
Structure and activation of muscarinic acetylcholine receptors
Biochemical Society Transactions, 2003A homology model of the M1 muscarinic acetylcholine receptor, based on the X-ray structure of bovine rhodopsin, has been used to interpret the results of scanning and point mutagenesis studies on the receptor's transmembrane (TM) domain. Potential intramolecular interactions that are important for the stability of the protein fold have been identified.
Zhi-Liang Lu +3 more
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