Results 201 to 210 of about 50,615 (267)

Activating Muscarinic Receptor Signaling in Intrapancreatic Neurons Is Required for Parasympathetic Cholinergic Control of Pancreatic Cell Function. [PDF]

Diabetes
Levi NJ, Tamayo Garcia A, Sokolov M, Barro-Soria R, Caicedo A.   +4 more
europepmc   +1 more source

FF/UMEC/VI and BUD/GLY/FORM in Patients with COPD Stepping Up from Dual Therapy Stratified by Exacerbations and Prior Dual Therapy: A Subgroup Analysis of a Comparative Effectiveness Study. [PDF]

Adv Ther
Wedzicha JA, Noorduyn SG, Di Boscio V, Le Rouzic O, Majumdar A, Paczkowski R, Weng S, Germain G, Laliberté F, Mannino D.   +9 more
europepmc   +1 more source

Activity-dependent muscarinic signalling regulates presynaptic PKC pathway and neurotransmission machinery at the neuromuscular junction. [PDF]

Cell Commun Signal
Polishchuk A, Just-Borràs L, Cilleros-Mañé V, Balanyà-Segura M, Silvera Simón C, Tomàs M, Jami El Hirchi M, Díaz-Wallach M, Hurtado E, Tomàs J, Lanuza MA.   +10 more
europepmc   +1 more source

Clinical Remission in Severe T2-High Asthma in Real Life After Anti-IgE, Anti-IL-5 and Anti-IL5R: A Potential Role for CRP as a Biomarker. [PDF]

Clin Transl Allergy
Vervier J, Sabbe M, Louis F, Moermans C, Guissard F, Sanchez C, Paulus V, Henket M, Philippe G, Beijnink CWH, Bridevaux PO, Schleich F, Louis R.   +12 more
europepmc   +1 more source

Long-acting β₂ agonist (LABA) with a long-acting muscarinic receptor antagonist (LAMA) promotes human airway smooth muscle (HASM) relaxation and circumvents β₂ adrenergic receptor tachyphylaxis. [PDF]

Respir Res
Jude J, Karmacharya N, Sherpa RT, O'Riordan TG, Koziol-White CJ, Panettieri RAJ.   +5 more
europepmc   +1 more source

Synergistic mechanisms of medullary cholinergic-serotonergic pathway interactions in regulating neuronal excitability and locomotor activities. [PDF]

Commun Biol
Cheng Y, Dai Y, Ge R, Zhang Q.
europepmc   +1 more source

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The discovery of AZD9164, a novel muscarinic M3 antagonist

Bioorganic and Medicinal Chemistry Letters, 2011
The optimization of a new series of muscarinic M(3) antagonists is described, leading to the identification of AZD9164 which was progressed into the clinic for evaluation of its potential as a treatment for COPD.
Antonio, Mete, Keith, Bowers, Eric, Chevalier, David K, Donald, Helen, Edwards, Katherine J, Escott, Rhonan, Ford, Ken, Grime, Ian, Millichip, Barry, Teobald, Vince, Russell   +10 more
exaly   +3 more sources

Muscarinic Receptor Antagonists

2016
Parasympathetic activity is increased in patients with chronic obstructive pulmonary disease (COPD) and asthma and appears to be the major reversible component of airway obstruction. Therefore, treatment with muscarinic receptor antagonists is an effective bronchodilator therapy in COPD and also in asthmatic patients.
Maria Gabriella, Matera, Mario, Cazzola
openaire   +2 more sources

Selective Muscarinic Receptor Agonists and Antagonists

Pharmacology & Toxicology, 1996
Abstract:Muscarinic receptors are composed of a family of four subtypes each of which can be distinguished pharmacologically and structurally. The physiological role of each subtype in the central and peripheral nervous systems remains to be clarified, due, in part, to a lack of agonists and antagonists with adequate subtype selectivity.
R M, Eglen, N, Watson
openaire   +2 more sources