Results 211 to 220 of about 50,615 (267)

Role of muscarinic antagonists in asthma therapy

Expert Review of Respiratory Medicine, 2017
Higher parasympathetic tone has been reported in asthmatics. In general, cholinergic contractile tone is increased by airway inflammation associated with asthma. Nevertheless, the role of muscarinic antagonists for the treatment of asthma has not yet been clearly defined.
CAZZOLA, MARIO, Ora, J, ROGLIANI, PAOLA, Matera, Mg   +3 more
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Quinidine as a muscarinic antagonist: A structural approach

Journal of Pharmaceutical Sciences, 1992
The synthesis, spectroscopic characteristics, and single-crystal X-ray structural analysis of quitenidine methyl ester monohydrate, a derivative of the muscarinic antagonist quinidine, are presented. Quitenidine methyl ester monohydrate (C20H24N2O4.H2O) crystallizes in the orthorhombic space group P2(1)2(1)2(1), with a = 16.69(3) A, b = 12.46(2) A, c =
M, Ciechanowicz-Rutkowska, B J, Oleksyn, A, Suszko-Purzycka, T, Lipińska   +3 more
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Design and synthesis of a fluorescent muscarinic antagonist

Bioorganic & Medicinal Chemistry Letters, 2008
The design and concise synthesis of a fluorescent tolterodine-BODIPY (boron dipyrromethene) conjugate is described which possesses potent antimuscarinic activity. This derivative illustrates proof-of-concept for the preparation of other useful fluorophoric antimuscarinic agents which have potential utility in receptor occupancy studies and high ...
Lyn H, Jones, Amy, Randall, Carolyn, Napier, Mike, Trevethick, Sasha, Sreckovic, Jessica, Watson   +5 more
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Binding of agonists and antagonists to muscarinic receptors

Journal of Supramolecular Structure, 1976
AbstractThe binding of one irreversible and two reversible radioactive antagonists to muscarinic receptors in synaptosome preparations of rat cerebral cortex has been studied. The ligands all bind to the same receptor pool and directly and competitively yield self‐consistent binding constants closely similar to those obtained by pharmacological methods
N J, Birdsall, A S, Burgen, C R, Hiley, E C, Hulme   +3 more
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MUSCARINIC RECEPTOR ANTAGONISTS

1991
A muscarinic receptor antagonist of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is N or (a) where R is H, halo or C1-C4 alkyl; R is H or C1-C4 alkyl; R is H or C1-C4 alkyl; Y is a direct link, O or S; m is an integer of from 1 to 4; n is 2 or 3; and R is 1- or 2-naphthyl or a group of formula (b), (c) or Het where R and R are ...
PFIZER LTD, PFIZER
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Allosteric antagonists of the muscarinic acetylcholine receptor

Biochemical Pharmacology, 1991
For the most part, the interaction of these selective antagonists with muscarinic receptors has been interpreted in the context of simple competitive bimolecular reaction which obeys the law of mass action. In fact, the use of selective antagonists as a pharmacological tool to identify receptor types and subtypes is based on this premise.
N H, Lee, E E, el-Fakahany
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Long-acting muscarinic antagonists

Expert Review of Clinical Pharmacology, 2015
Chronic obstructive pulmonary disease (COPD) is a major cause of death and disability worldwide. Inhaled bronchodilators are the mainstay of COPD pharmacological treatment. Long-acting muscarinic antagonists (LAMAs) are a major class of inhaled bronchodilators.
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Aprophit: An irreversible antagonist for muscarinic receptors

Biochemical Pharmacology, 1990
The development of selective irreversible ligands has proven to be an invaluable technique for the isolation, purification and characterization of many receptor proteins. An isothiocyanato-derivative of the muscarinic antagonist aprophen was synthesized and evaluated as a potential irreversible ligand for muscarinic receptors.
A H, Newman, J, Covington, M, Oleshansky, B W, Jackson, B A, Weissman, H, Leader, P K, Chiang   +6 more
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[Selective muscarinic receptor antagonists].

Nihon rinsho. Japanese journal of clinical medicine, 1984
to ex- plain the anomalous binding of cholin- ergic agonists to brain receptors~ were later demonstrated with the seEective muscarinic antagonist, pirenzepine 2. Interestingly, the search for selective antagonists, which usually follows the acceptance of a concept, antedated by many years the notion of heterogeneity of rmecarinic receptors. Intuitively
S, Kishimoto, G, Kajiyama, A, Miyoshi
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Muscarinic receptor antagonists for overactive bladder

BJU International, 2007
From time to time we publish a full review of drugs that are available for the treatment of common conditions. In this issue, the review is written by two of the leading authorities in the world, Paul Abrams and Karl‐Erik Andersson, on the topic of overactive bladder and antimuscarinic agents.
Paul, Abrams, Karl-Erik, Andersson
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