Results 321 to 330 of about 2,360,825 (374)

Heterogeneity of vascular muscarinic receptors

Journal of Autonomic Pharmacology, 1990
SummaryMuscarinic receptors mediate diverse effects on the vasculature. Recently, a consensus has been arrived at with regard to muscarinic receptor classification (Levine and Birdsall, 1989). As a result, it may now be possible to clarify the role of each subtype in the responses of vascular tissues to muscarinic agonists. It is apparent that vascular
R. L. Whiting, R. M. Eglen
openaire   +3 more sources

Regulation of muscarinic M2 receptors

Life Sciences, 1997
The molecular mechanisms involved in the regulation of muscarinic receptor gene expression are poorly understood. In an effort to gain a better understanding of the regulation of M2 receptors, we have investigated homologous and heterologous regulation of M2 muscarinic receptor protein and gene expression in human embryonic lung fibroblasts (HEL 299 ...
Jonathan Rousell, Peter J. Barnes, El-Bdaoui Haddad   +2 more
openaire   +2 more sources

Muscarinic Acetylcholine Receptors

2004
Muscarinic acetylcholine receptors are members of the G-protein-coupled receptor superfamily. There are five genes encoding the muscarinic receptors, which are expressed to different extents in a variety of tissues, including cardiac and smooth muscle, secretory glands, and neurons and glial cells in the central and peripheral nervous systems ...
openaire   +2 more sources

Structure and Regulation of Muscarinic Receptors

Annual Review of Physiology, 1989
Our knowledge of muscarinic receptor structure, mechanism, and regulation has increased enormously over the past five years. At this time, expression of receptor subtype and coupling via signal transducing elements to specific effector systems seems to be cell or tissue specific events.
openaire   +3 more sources

Muscarinic receptor subtypes in airways

European Respiratory Journal, 1993
Muscarinic receptor subtypes in the airways appear to subserve different physiological functions. M1-receptors facilitate neurotransmission through parasympathetic ganglia and enhance cholinergic reflexes, but are also localized to alveolar walls. M2-receptors act as autoreceptors on post-ganglionic cholinergic nerves and inhibit acetylcholine release.
openaire   +4 more sources

Endocytosis and recycling of muscarinic receptors

Life Sciences, 1999
Agonist stimulation causes the endocytosis of many G protein-coupled receptors, including muscarinic acetylcholine receptors. In this study we have investigated the agonist-triggered trafficking of the M3 muscarinic receptor expressed in SH-SY5Y human neuroblastoma cells.
J. Michael Edwardson, Philip G. Szekeres
openaire   +3 more sources

Functional nicotinic and muscarinic receptors on mesenchymal stem cells.

Stem Cells and Development, 2009
Mesenchymal stem cells (MSCs) are under the control of a large number of signaling systems. In this study, the presence and functionality of the acetylcholine (ACh) signaling system in MSCs was examined.
M. Hoogduijn, A. Cheng, P. Genever
semanticscholar   +1 more source

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors.

Science, 1992
Altered processing of the amyloid precursor protein (APP) is a central event in the formation of amyloid deposits in the brains of individuals with Alzheimer's disease.
R. Nitsch, B. Slack, R. J. Wurtman, J. Growdon   +3 more
semanticscholar   +1 more source

Muscarinic Acetylcholine Receptors

1988
The central and peripheral actions of the endogenous neurotransmitter acetylcholine (ACh) are exerted at two main types of receptor, present in both the central and peripheral nervous system of all mammals. Their definition and pharmacological classification dates back to the work of Sir Henry Dale (1914), who demonstrated that certain actions of ACh ...
J. Järv, Tamas Bartfai
openaire   +2 more sources

Constitutively active muscarinic receptors

Life Sciences, 2001
Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin.
Ethan S. Burstein, Tracy A. Spalding
openaire   +2 more sources