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Airway Smooth Muscle in Asthma
Annual Review of Pathology: Mechanisms of Disease, 2004Airway smooth muscle plays a multifaceted role in the pathogenesis of asthma. We review the current understanding of the contribution of airway myocytes to airway inflammation, airway wall remodeling, and airflow obstruction in this prevalent disease syndrome. Together, these roles make airway smooth muscle an attractive target for asthma therapy.
Julian Solway +3 more
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Ca2+ Movements in Smooth Muscle
Chest, 1980We describe the Ca2+ movements in smooth muscle cells at rest and during activation and relaxation as deduced from transplasmalemmal Ca2+ fluxes and contractile respnses. The general picture which emerges is: the resting cell has a [Ca2+]cyt below 10(-7) M and large gradients are poised across both the cell membrane and intracellular membranes ...
R. Loutzenhiser +3 more
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Calcium sparks in smooth muscle
American Journal of Physiology-Cell Physiology, 2000Local intracellular Ca2+transients, termed Ca2+sparks, are caused by the coordinated opening of a cluster of ryanodine-sensitive Ca2+release channels in the sarcoplasmic reticulum of smooth muscle cells. Ca2+sparks are activated by Ca2+entry through dihydropyridine-sensitive voltage-dependent Ca2+channels, although the precise mechanisms of ...
Nelson, MT. +3 more
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Canadian Journal of Biochemistry and Physiology, 1958
The sodium, potassium, chloride, and water concentrations have been analyzed in relatively pure smooth muscles of electrophysiological interest and compared to similar analyses of other muscle types. The smooth muscles analyzed included isolated longitudinal myometrium from the uteri of various species and the taenia coli from guinea pigs and rabbits.
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The sodium, potassium, chloride, and water concentrations have been analyzed in relatively pure smooth muscles of electrophysiological interest and compared to similar analyses of other muscle types. The smooth muscles analyzed included isolated longitudinal myometrium from the uteri of various species and the taenia coli from guinea pigs and rabbits.
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The Contractile Apparatus of Smooth Muscle
1980Publisher Summary This chapter describes the architecture of the contractile apparatus. Smooth muscle cells, when isolated, are generally spindle-like in shape with tapered ends and possess a centrally placed, elongated nucleus. In vivo, where the cells occur in bundles and overlapping layers, they adapt themselves to the contours of the tissue; in
Sobieszek A, Small Jv
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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
Nature, 1997M. Uehata +10 more
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Vascular smooth muscle cells in atherosclerosis
Nature Reviews Cardiology, 2019Gemma Basatemur +4 more
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1986
Muscles of inner organs of vertebrates, such as gut, uterus, bronchial tree and blood vessels, are termed “smooth muscles” as they lack ordinary striations. Smooth muscles may be spontaneously active, or they may contract in response to nervous or hormonal stimulation.
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Muscles of inner organs of vertebrates, such as gut, uterus, bronchial tree and blood vessels, are termed “smooth muscles” as they lack ordinary striations. Smooth muscles may be spontaneously active, or they may contract in response to nervous or hormonal stimulation.
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Smooth Musculature. Smooth Muscle Cells
1985This three-dimensional figure illustrates the plane of contact between the longitudinally and circularly coursing muscle layers of the tunica muscularis of the intestine. In addition to the nuclei (1) and endoplasm (2) with its organelles, the muscle cells can be seen to contain longitudinally oriented microfilaments (3), dense bodies (4), a peripheral
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