Results 261 to 270 of about 261,565 (352)

Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti‐PD‐1 immunotherapy efficacy in colorectal cancer liver metastasis

Cancer Communications, EarlyView.
Abstract Background Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor‐associated macrophages (TAMs) play a critical role in modulating immune responses and exhibit significant heterogeneity in CRLM.
Yizhi Zhan, Jinsong Xu, Zhanqiao Zhang, Yating Hu, Yongsheng Li, Junying Qian, Yunyan Ling, Dehua Wu, Haijun Deng, Guoxin Li, Zhiyong Shen, Yuan Fang   +11 more
wiley   +1 more source

Enzyme response to thyrotoxicosis and hypothyroidism in human liver and muscle [PDF]

, 1972
Bachmaier, B., Kiefhaber, P., Nolte, J., Pette, D., Schneider, H., Scriba, Peter Christian   +5 more
core  

Treatments of unesthetic amalgam tattoo: A literature review and a case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background An amalgam tattoo is an iatrogenic lesion that can lead to esthetic concerns. This paper presents a literature review aimed at exploring treatment options available to clinicians for addressing this unesthetic issue. Methods The initial search identified 209 potentially relevant publications.
Lucrezia Parma‐Benfenati, Saeed A. Elrefaei, Hom‐Lay Wang, Muhammad H. A. Saleh   +3 more
wiley   +1 more source

Ribonuclear inclusions as biomarker of myotonic dystrophy type 2, even in improperly frozen or defrozen skeletal muscle biopsies

, 2009
Rosanna Cardani, E. Mancinelli, Marzia Giagnacovo, Valeria Sansone, G. Meola   +4 more
openalex   +2 more sources

Honeycomb or Lotus Root‐Like Intracoronary Pattern: Insights From Optical Coherence Tomography of a Recanalized Thrombus

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Spontaneous recanalized coronary thrombus (SRCT) has been identified in autopsy studies as multiple interconnected channels separated by thin septa. Despite its potential clinical significance, SRCT remains underdiagnosed. Recent advances in intracoronary imaging, including optical coherence tomography (OCT), have elucidated its ...
Fernando Quevedo, Julio Farjat, Olivier Bertrand, Anthony Poulin, Jean Pierre Déry, David Garcia‐Labbé, Can Nguyen, Jean Michel Paradis, Natalia Pinilla, Tomas Cieza   +9 more
wiley   +1 more source

Muscle Biopsy [PDF]

Journal of Clinical Pathology, 1986
openaire   +1 more source

Actin Filament Pointed Ends: Assays for Regulation of Assembly and Disassembly by Tropomodulin and Tropomyosin

Cytoskeleton, EarlyView.
ABSTRACT Actin filaments are dynamic polymers whose length depends on regulated monomer association and dissociation at their ends. Actin barbed‐end dynamics are relatively better understood, primarily due to the approximately tenfold faster subunit on/off rates at barbed versus pointed ends.
Sawako Yamashiro, Shashank Shekhar, Stefanie M. Novak, Sudipta Biswas, Carol C. Gregorio, Velia M. Fowler   +5 more
wiley   +1 more source

Profiling a Neo‐Antigen‐Driven Immune Response in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled Study of the KLH Challenge Model

Clinical Pharmacology &Therapeutics, EarlyView.
Novel compounds targeting the adaptive immune system are commonly initially investigated in healthy volunteers (HV). HV frequently lack constitutively expressed drug‐target engagement biomarkers, complicating the evaluation of pharmacological activity. The keyhole limpet hemocyanin (KLH) neo‐antigen challenge elicits a controlled immune response in HV ...
Micha N. Ronner, Hendrika W. Grievink, Mahdi Saghari, Michelle Osse, Thierry P.P. van den Bosch, Jeffrey Damman, Marieke L. de Kam, Jacobus Burggraaf, Naomi B. Klarenbeek, Manon A. A. Jansen, Matthijs Moerland   +10 more
wiley   +1 more source

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source

Spatial transcriptomic analysis of muscle biopsy from treatment-naive juvenile dermatomyositis patients reveals mitochondrial abnormalities despite disease-related interferon driven signature

Syntakas AE, Kartawinata M, Evans NML, Nguyen HD, Papadopoulou C, Al Obaidi M, Pilkington C, Glackin Y, Mahoney CB, Croft AP, Eaton S, Cortina-Borja M, Ogunbiyi O, Merve A, Wedderburn LR, Wilkinson MGL.   +15 more
europepmc   +1 more source