Results 281 to 290 of about 261,565 (352)

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

European Journal of Heart Failure, EarlyView.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, Bianca J.J.M. Brundel, Gemma Chiva‐Blanch, Sean M. Davidson, Dana Dawson, Fabio Di Lisa, Paul Evans, Zoltan Giricz, Derek J. Hausenloy, Petra Kleinbongard, Frank Lezoualc'h, Elisa Liehn, Christoph Maack, Ange Maguy, Elizabeth Murphy, Cinzia Perrino, Maurizio Pesce, Peter P. Rainer, Katrin Streckfuss‐Bömeke, Matthias Thielmann, Rong Tian, Carlo G. Tocchetti, Jolanda Van Der Velden, Sophie Van Linthout, Serena Zacchigna, Thomas Krieg   +29 more
wiley   +1 more source

Genotype‐guided cardiac device intervention in LMNA‐related cardiac conduction disorder: The need for timely genetic testing

European Journal of Heart Failure, EarlyView.
Sudden cardiac death is a catastrophic event, making its prevention important. However, patient selection for primary prevention remains controversial. We report two cases of cardiac conduction disorder initially treated with permanent pacemaker implantation.
Shunsuke Inoue, Zhehao Dai, Tsukasa Oshima, Seitaro Nomura, Takashi Hiruma, Ryo Abe, Kanna Fujita, Manami Katoh, Toshiyuki Ko, Yu Shimizu, Masamichi Ito, Kenichiro Yamagata, Junichi Ishida, Eisuke Amiya, Masaru Hatano, Norifumi Takeda, Hiroyuki Morita, Katsuhito Fujiu, Norihiko Takeda, Issei Komuro   +19 more
wiley   +1 more source

Clustering in dilated cardiomyopathy at initial evaluation: An effective tool for clinical stratification

European Journal of Heart Failure, EarlyView.
Visual description of study design and main results. BBB, bundle branch block; ECG, electrocardiogram; MVA, major ventricular arrhythmia; SCD, sudden cardiac death. Abstract Aims Dilated cardiomyopathy (DCM) has a highly variable presentation and disease course. Current stratification strategies are complex and require multimodality evaluation.
Ilaria Gandin, Maria Perotto, Alessia Paldino, Giovanni Baj, Denise Zaffalon, Andrea Pezzato, Cinzia Crescenzi, Fabiana Romeo, Annamaria Martino, Francesca Fanisio, Federica Toto, Maddalena Rossi, Marta Gigli, Matteo Dal Ferro, Leonardo Calò, Gianfranco Sinagra, Marco Merlo   +16 more
wiley   +1 more source

Seizures and electroencephalographic findings in inborn errors of metabolism: Clues to differential diagnosis in the neonatal period, infancy, childhood and adolescence, and review of the literature

Epileptic Disorders, EarlyView.
Abstract Although inborn errors of metabolism (IEM) are a rare cause of epilepsy, seizures are a common presentation in these disorders. Seizures in IEM are frequently refractory to conventional anti‐seizure medication and might warrant initiation of specific treatments based on vitamins or dietary modifications or provision of alternative substrates ...
D. Kapoor, S. Sharma, A. Kaminska, R. Nabbout, N. Chemaly, M. Schiff, P. De Lonlay, M. Eisermann   +7 more
wiley   +1 more source

Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing

Glia, EarlyView.
Hypothalamic astrocytes versus cortical astrocytes: are more glycolytic due to high Pkm2, Glut1 and Mct4 expression do not exhibit glutamate‐induced glycolysis detect glucose concentration variations via an AMPK sensor with altered lactate production. ABSTRACT In the hypothalamus, detection of energy substrates such as glucose is essential to regulate ...
Sarah Geller, Nadège Zanou, Sylviane Lagarrigue, Tamara Zehnder, Cathy Gouelle, Tania Santoro, Cendrine Repond, Paola Bezzi, Francesca Amati, Anne‐Karine Bouzier‐Sore, Ariane Sharif, Luc Pellerin   +11 more
wiley   +1 more source

Macrophage Targeting Protects Nerve Structure and Improves Muscle Innervation in a Mouse Model of Charcot‐Marie‐Tooth 2J

Glia, EarlyView.
Hemizygous P0T124M mice develop a late‐onset axonopathy at 18 months of age. Pharmacological macrophage targeting with PLX5622 prevents distal axon degeneration in P0T124M mutant mice and mitigates motor impairment. ABSTRACT In several previous studies, we have shown that macrophage targeting with the CSF‐1 receptor specific kinase (c‐FMS) inhibitor ...
Dennis Klein, Neslim Ercan, Xidi Yuan, Ghjuvan' Ghjacumu Shackleford, Anke Claessens, M. Laura Feltri, Lawrence Wrabetz, Maurizio D'Antonio, Rudolf Martini   +8 more
wiley   +1 more source

The Role of Machine Learning to Detect Occult Neck Lymph Node Metastases in Early‐Stage (T1‐T2/N0) Oral Cavity Carcinomas

Head &Neck, EarlyView.
ABSTRACT Objective Oral cavity carcinomas (OCCs) represent roughly 50% of all head and neck cancers. The risk of occult neck metastases for early‐stage OCCs ranges from 15% to 35%, hence the need to develop tools that can support the diagnosis of detecting these neck metastases.
Stefania Troise, Lorenzo Ugga, Maria Esposito, Maria Positano, Andrea Elefante, Serena Capasso, Renato Cuocolo, Raffaele Merola, Umberto Committeri, Vincenzo Abbate, Paola Bonavolontà, Riccardo Nocini, Giovanni Dell’Aversana Orabona   +12 more
wiley   +1 more source

Human renal transplants. 3. Immunopathologic studies. [PDF]

, 1970
Accinni, L, Andres, GA, Hsu, KC, Penn, I, Porter, KA, Rendall, JM, Seegal, BC, Starzl, TE   +7 more
core  

Yield of Muscle Biopsy in Patients with Findings of Myopathy on Electrodiagnostic Testing.

J Neurosci Rural Pract, 2019
Siddiqui SH, Ahmed R, Awan S, Zain A, Khan S.   +4 more
europepmc   +1 more source

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Muscle biopsy

Journal of Neurology, 2011
Muscle biopsy is required to provide a definitive diagnosis in many neuromuscular disorders. It can be performed through an open or needle technique under local anesthesia. The major limitations of the needle biopsy technique are the sample size, which is smaller than that obtained with open biopsy, and the impossibility of direct visualization of the ...
G. Meola, E. Bugiardini, R. Cardani
openaire   +3 more sources