Results 241 to 250 of about 2,181,626 (304)

Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle.

Science, 1993
Spontaneous local increases in the concentration of intracellular calcium, called "calcium sparks," were detected in quiescent rat heart cells with a laser scanning confocal microscope and the fluorescent calcium indicator fluo-3.
Heping Cheng, W. Lederer, M. Cannell
semanticscholar   +1 more source

Structure of the actin-myosin complex and its implications for muscle contraction.

Science, 1993
Muscle contraction consists of a cyclical interaction between myosin and actin driven by the concomitant hydrolysis of adenosine triphosphate (ATP). A model for the rigor complex of F actin and the myosin head was obtained by combining the molecular ...
I. Rayment, H. Holden, M. Whittaker, C. B. Yohn, M. Lorenz, K. Holmes, R. Milligan   +6 more
semanticscholar   +1 more source

Mysteries of Muscle Contraction

Journal of Applied Biomechanics, 2008
According to the cross-bridge theory, the steady-state isometric force of a muscle is given by the amount of actin–myosin filament overlap. However, it has been known for more than half a century that steady-state forces depend crucially on contractile history. Here, we examine history-dependent steady-state force production in view of the cross-bridge
Venus Joumaa, Ashi Mehta, Walter Herzog, Tim Leonard   +3 more
openaire   +2 more sources

Regulation of contraction in striated muscle.

Physiological Reviews, 2000
Ca(2+) regulation of contraction in vertebrate striated muscle is exerted primarily through effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural and biochemical studies suggest that the position of tropomyosin (Tm)
A. M. Gordon, E. Homsher, M. Regnier
semanticscholar   +1 more source

Muscle physiology and contraction

Surgery (Oxford), 2013
Abstract Skeletal muscle has important metabolic functions but the focus of this article is to examine its ability to generate mechanical force. Adult skeletal muscle fibres are each innervated by a single branch of the axon arising from an α-motoneuron in the spinal cord. The α-motoneuron and all the fibres it innervates constitute a motor unit, and
Carolyn A. Greig, Carolyn A. Greig, David A. Jones, David A. Jones   +3 more
openaire   +2 more sources

Mechanism of muscle contraction

Technology and Health Care, 1993
This work is the first attempt to propose a complex model of muscle contraction in which different aspects of the sarcomere shortening are collected into a logical entity. Proposed are some suggestions to answer some fundamental questions concerning the molecular mechanism of muscle contraction, such as the following: "of which part of the myosin ...
openaire   +3 more sources

Theories of Muscle Contraction

Journal of Structural Biology, 1995
A survey of the mainstream theories in the modern study of the mechanism of muscle contraction is made, with particular emphasis placed on the experimental results which most influenced the progression of ideas. Starting with early elastic and viscoelastic theories of muscle contraction, a chronological organization is used to present, in detail, the ...
openaire   +3 more sources

Toward a theory of muscle contraction [PDF]

Journal of Bioenergetics, 1972
The general chemistry of muscle contraction was elucidated early on from test-tube reconstitutions of function:1, 2 Myosin and actin form an ATP-dissociable complex; myosin is an actin-modifiable ATPase, and the free energy of ATP hydrolysis “pays for” any work performed in contraction. The central structural feature of contraction was discovered later:
Gustavo Viniegra-Gonzalez, Manuel F. Morales   +1 more
openaire   +2 more sources

Critical illness myopathy and GLUT4: significance of insulin and muscle contraction.

American Journal of Respiratory and Critical Care Medicine, 2013
RATIONALE Critical illness myopathy (CIM) has no known cause and no treatment. Immobilization and impaired glucose metabolism are implicated. OBJECTIVES We assessed signal transduction in skeletal muscle of patients at risk for CIM.
S. Weber-Carstens, Joanna Schneider, T. Wollersheim, A. Assmann, J. Bierbrauer, Andreas Marg, H. Al Hasani, A. Chadt, K. Wenzel, S. Koch, J. Fielitz, C. Kleber, K. Faust, K. Mai, C. Spies, F. Luft, M. Boschmann, J. Spranger, S. Spuler   +18 more
semanticscholar   +1 more source

Regulation of Muscle Contraction

1983
The discovery of troponin (Ebashi and Kodama, 1965; cf. Ebashi et al., 1969) established the concept of regulation in muscle contraction and the term regulatory proteins (Maruyama and Ebashi, 1970). The absence of troponin or other specific regulatory proteins in molluscan striated muscle (Kendrick-Jones et al., 1970) suggested that the mode of ...
openaire   +4 more sources