Results 21 to 30 of about 2,186,751 (353)
RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. [PDF]
, 2020 Elevated cytoplasmic [Ca2+] is characteristic in severe skeletal and cardiac myopathies, diabetes, and neurodegeneration, and partly results from increased Ca2+ leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels ...
Bers, Donald M +6 more
core +2 more sources
A Piezoresistive Sensor to Measure Muscle Contraction and Mechanomyography
Italian National Conference on Sensors, 2018 Measurement of muscle contraction is mainly achieved through electromyography (EMG) and is an area of interest for many biomedical applications, including prosthesis control and human machine interface. However, EMG has some drawbacks, and there are also
D. Esposito +6 more
semanticscholar +1 more source
The Multi-Scale, Three-Dimensional Nature of Skeletal Muscle Contraction.
Physiology, 2019 Muscle contraction is a three-dimensional process, as anyone who has observed a bulging muscle knows. Recent studies suggest that the three-dimensional nature of muscle contraction influences its mechanical output.
T. Roberts +7 more
semanticscholar +1 more source
The coagulation of myosin in muscle [PDF]
, 1937 The coagulation of myosin is one of the few changes in the proteins of muscle known to take place during contraction and rigor. Although under certain conditions as much as one-third of the total protein of muscle may become insoluble, the significance ...
Mirsky, A. E.
core +2 more sources
Ultrasound in Obstetrics and Gynecology, 2019 To determine intra‐ and interrater reliability and agreement for ultrasound measurements of pelvic floor muscle contraction and to assess the correlation between ultrasound and vaginal palpation.
M. Nyhus +6 more
semanticscholar +1 more source
Endurance training facilitates myoglobin desaturation during muscle contraction in rat skeletal muscle. [PDF]
, 2015 At onset of muscle contraction, myoglobin (Mb) immediately releases its bound O2 to the mitochondria. Accordingly, intracellular O2 tension (PmbO2) markedly declines in order to increase muscle O2 uptake (mVO2).
Furuichi, Yasuro +9 more
core +1 more source
α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism. [PDF]
, 2016 Coordinated gastrointestinal smooth muscle contraction is critical for proper nutrient absorption and is altered in a number of medical disorders. In this work, we demonstrate a critical role for the RGD-binding integrin α8β1 in promoting nutrient ...
Atabai, Kamran +12 more
core +2 more sources
Pharmacological Reviews, 2016 The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases ...
F. Brozovich +5 more
semanticscholar +1 more source
A circuit mechanism for the propagation of waves of muscle contraction in Drosophila
eLife, 2016 Animals move by adaptively coordinating the sequential activation of muscles. The circuit mechanisms underlying coordinated locomotion are poorly understood. Here, we report on a novel circuit for the propagation of waves of muscle contraction, using the
Akira Fushiki +5 more
semanticscholar +1 more source
Frontiers in Molecular Neuroscience, 2017 The neurotrophin brain-derived neurotrophic factor (BDNF) acts via tropomyosin-related kinase B receptor (TrkB) to regulate synapse maintenance and function in the neuromuscular system.
Erica Hurtado +11 more
semanticscholar +1 more source