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Structural Mechanism of Muscle Contraction
Annual Review of Biochemistry, 1999▪ Abstract X-ray crystallography shows the myosin cross-bridge to exist in two conformations, the beginning and end of the “power stroke.” A long lever-arm undergoes a 60° to 70° rotation between the two states. This rotation is coupled with changes in the active site (OPEN to CLOSED) and phosphate release.
Geeves, M., Holmes, K.
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Muscle Contraction and Fibrous Muscle Proteins
1952Publisher Summary This chapter deals with the contraction of different kinds of muscle that show differences with respect to the amount of tension developed, the maximum shortening, the rate of shortening, and the fuel requirement. These differences not only reflect the varying levels of evolutionary development, but also a considerable adaptation to
Hans H. Weber, Hildegard Portzehl
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Novartis Foundation symposium, 1998
Understanding muscle contraction goes to the heart of one of the fundamental questions posed by classical philosophy, namely the nature of the pi nu epsilon upsilon mu alpha psi nu chi iota kappa omicron nu. The nature of 'understanding' has altered greatly during the last two millenia, particularly in response to the development of the concept of ...
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Understanding muscle contraction goes to the heart of one of the fundamental questions posed by classical philosophy, namely the nature of the pi nu epsilon upsilon mu alpha psi nu chi iota kappa omicron nu. The nature of 'understanding' has altered greatly during the last two millenia, particularly in response to the development of the concept of ...
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Muscle Filament Structure and Muscle Contraction
Annual Review of Biophysics and Bioengineering, 1975Research into the mechanism of muscle contraction has reached a very intriguing stage. It now seems likely that all types of muscle may operate in basically the same way. But despite the present detailed knowledge of the molecular arrangements in certain muscles, the precise way in which a muscle generates force is still a mystery. According to the now
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The Molecular Mechanism of Muscle Contraction
2005Publisher Summary This chapter describes the analysis of the polymorphism of the myosin crossbridge and relates it to the Lymn–Taylor crossbridge cycle. Myosin from muscle (myosin II) consists of two long polypeptide chains (heavy chains) combined with four light chains.
Geeves, M., Holmes, K.
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A Molecular Model for Muscle Contraction
Acta Crystallographica Section A Foundations of Crystallography, 1998The molecular mechanism of muscle contraction has been elucidated by a combination of electron microscopy, biochemistry and X-ray diffraction from fibres and crystals. Protein crystallography provided the essential molecular anatomy for understanding this problem. Synchrotron radiation has played a crucial role.
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Muscle Excitation and Contraction
1986In the most primitive muscle cells, the myocytes of sponges, contractile phenomena are entirely regulated at a cellular level. In contrast, in all higher phyla, motility is more or less under the control of the nervous system which communicates with muscle cells at the neuromuscular junction. Think, for example, of a frog jumping into a pond.
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Contraction Dynamics in Antagonist Muscles
Journal of Theoretical Biology, 1994By taking into account the torque/angle and the torque/angular speed relationships of antagonist muscles acting across a joint it is possible to predict the contraction dynamics when they are simultaneously activated at a constant level. The simulation is displayed in a "phase-plane" where trajectories for each starting condition (angle--abscissa ...
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Control of satellite cell function in muscle regeneration and its disruption in ageing
Nature Reviews Molecular Cell Biology, 2022Pedro Sousa-Victor, Pura Muñoz-Cánoves
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