Results 41 to 50 of about 490,179 (385)

α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism. [PDF]

, 2016
Coordinated gastrointestinal smooth muscle contraction is critical for proper nutrient absorption and is altered in a number of medical disorders. In this work, we demonstrate a critical role for the RGD-binding integrin α8β1 in promoting nutrient ...
Atabai, Kamran, Azary, Saeedeh, Ha, Arnold, Hart, Daniel, Khalifeh-Soltani, Amin, McCarthy, Donald A, McKleroy, William, Podolsky, Michael J, Sakuma, Stephen, Stahl, Andreas, Tharp, Kevin M, Wu, Nanyan, Yokosaki, Yasuyuki   +12 more
core   +2 more sources

Structure of the Inhibited Smooth Muscle Myosin and Its Implications on the Regulation of Insect Striated Muscle Myosin

Life
Class II myosin (myosin-2) is an actin-based motor protein found in nearly all eukaryotes. One critical question is how the motor function of myosin-2 is regulated. Vertebrate myosin-2 comprises non-muscle myosin, smooth muscle myosin and striated muscle
Shaopeng Sun, Yi-Ning Lu, Xiang-dong Li
doaj   +1 more source

Multiscale Modeling of Skeletal Muscle Active Contraction in Relation to Mechanochemical Coupling of Molecular Motors

Micromachines, 2015
In this work, a mathematical model was developed to relate the mechanochemical characterizations of molecular motors with the macroscopic manifestation of muscle contraction.
Jiangcheng Chen, Xiaodong Zhang, Shengmao Lin, He Wang, Linxia Gu   +4 more
doaj   +1 more source

Dynamics of PO2 and VO2 in resting and contracting rat spinotrapezius muscle

Frontiers in Physiology, 2023
This study examined changes in interstitial PO2, which allowed calculation of VO2 during periods of rest, muscle contraction and recovery using an in situ rat spinotrapezius muscle preparation.
Aleksander S. Golub, Aleksander S. Golub, Bjorn K. Song, Bjorn K. Song, William H. Nugent, William H. Nugent, Roland N. Pittman   +6 more
doaj   +1 more source

Dynamic muscle quality of the plantar flexors is impaired in claudicant patients with peripheral arterial disease and associated with poorer walking endurance [PDF]

, 2015
Objective Peripheral arterial disease and intermittent claudication (PAD-IC) negatively affects physical activity and function. There is evidence for plantarflexor muscle dysfunction and weakness; however, the extent to which this dysfunction can be ...
King, Stephanie, O'Brien, Thomas D., Vanicek, Natalie   +2 more
core   +1 more source

Identification of a third myosin-5a-melanophilin interaction that mediates the association of myosin-5a with melanosomes

eLife
Transport and localization of melanosome at the periphery region of melanocyte are depended on myosin-5a (Myo5a), which associates with melanosome by interacting with its adaptor protein melanophilin (Mlph).
Jiabin Pan, Rui Zhou, Lin-Lin Yao, Jie Zhang, Ning Zhang, Qing-Juan Cao, Shaopeng Sun, Xiang-dong Li   +7 more
doaj   +1 more source

Investigating the Correlation between Force Output, Strains, and Pressure for Active Skeletal Muscle Contractions [PDF]

arXiv, 2023
Experimental observations suggest that the force output of the skeletal muscle tissue can be correlated to the intra-muscular pressure generated by the muscle belly. However, pressure often proves difficult to measure through in-vivo tests. Simulations on the other hand, offer a tool to model muscle contractions and analyze the relationship between ...
arxiv  

Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy. [PDF]

, 2017
Transverse (T)-tubules make-up a specialized network of tubulated muscle cell membranes involved in excitation-contraction coupling for power of contraction. Little is known about how T-tubules maintain highly organized structures and contacts throughout
Fujita, Naonobu, Fukuda, Mitsunori, Groulx, Jean-Francois, Huang, Wilson, Jean, Steve, Kiger, Amy A, Koyama-Honda, Ikuko, Kuchitsu, Yoshihiko, Lin, Tzu-Han, Mizushima, Noboru, Nguyen, Jen   +10 more
core   +2 more sources

The Mechanism of Muscle Contraction [PDF]

Proceedings of the National Academy of Sciences, 1974
Muscular contraction is essentially the shortening of the S 2 subunits of heavy meromyosin, integrated to macroscopic motion by the thick and thin filaments.
openaire   +3 more sources

Determination of Dissociation Constants for the Interaction of Myosin-5a with its Cargo Protein Using Microscale Thermophoresis (MST)

Bio-Protocol
Myosin-5a (Myo5a) is an actin-dependent molecular motor that recognizes a diverse range of cargo proteins through its tail domain, playing a crucial role in the transport and localization of various organelles within the cell.
Rui Zhou, Jiabin Pan, Xiang-Dong Li
doaj   +1 more source