Results 51 to 60 of about 269,034 (318)

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Essential Role of ATP Synthesized by Creatine Kinase in Contraction of -Toxin Permeabilized Preparations of Tonic Type Smooth Muscle

Journal of Pharmacological Sciences, 2003
The role of ATP newly synthesized from ADP and phosphocreatine (PC) by creatine kinase (CK) in the contraction of tonic type smooth muscle, rat femoral artery was studied, since its necessity for phasic type smooth muscle was previously shown. In α-toxin-
Tadayoshi Takeuchi, Muneyoshi Kitayama, Masahiko Kushida, Akikazu Fujita, Fumiaki Hata   +4 more
doaj   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Expertise-Related Differences in Wrist Muscle Co-contraction in Drummers

Frontiers in Psychology, 2020
Background and Aim: Drumming requires excellent motor control and temporal coordination. Deploying specific muscle activation patterns may help achieve these requirements.
Scott Beveridge, Steffen A. Herff, Steffen A. Herff, Bryony Buck, Gerard Breaden Madden, Hans-Christian Jabusch   +5 more
doaj   +1 more source

Robocasting of a Water‐Based Biopolymer/WO3 Nanopowder Paste as a Precursor to Tungsten Carbide Lattices

Advanced Engineering Materials, EarlyView.
This study demonstrates a novel, additive manufacturing approach to produce complex, porous tungsten carbide structures using water‐based direct ink writing/robocasting. Leveraging a modified commercial printer and heat treatment, the process yields lightweight, electrically conductive 3D architectures capable of supporting a mechanical load.
James Bentley Bevis, Manasi Shah, Sanketh Gombi, Rodrigo Martinez‐Duarte   +3 more
wiley   +1 more source

Impact of contraction intensity and ankle joint angle on calf muscle fascicle length and pennation angle during isometric and dynamic contractions

Scientific Reports
During muscle contraction, not only are the fascicles shortening but also the pennation angle changes, which leads to a faster contraction of the muscle than of its fascicles. This phenomenon is called muscle gearing, and it has a direct influence on the
Corinna Coenning, Volker Rieg, Tobias Siebert, Veit Wank   +3 more
doaj   +1 more source

Remarks on Muscle Contraction Mechanism [PDF]

International Journal of Molecular Sciences, 2008
Muscle contraction mechanism is discussed by reforming the model described in an article by Mitsui (Adv. Biophys. 1999, 36, 107-158). A simple thermodynamic relationship is presented, which indicates that there is an inconsistency in the power stroke model or the swinging lever model. To avoid this difficulty, a new model is proposed.
Mitsui, Toshio, Ohshima, Hiroyuki
openaire   +3 more sources

Soft Beats: A Dielectric Elastomer‐Based Ventricular Assist Device for Next‐Gen Heart Failure Management

Advanced Engineering Materials, EarlyView.
The dielectric elastomer‐based electropneumatic device (DE‐EPD) is a vacuum‐assisted ventricular assist device (VAD) that delivers high performance (85 mmHg, 6.8 L min−1) with low power consumption. Unlike traditional motor‐driven VADs, it is lightweight, quiet, energy‐efficient, and provides pulsatile flow. Validated in a simulated circulation system,
Amine Benouhiba, Armando Walter, Silje Ekroll Jahren, Francesco Clavica, Dominik Obrist, Yoan Civet, Yves Perriard   +6 more
wiley   +1 more source

Exaggerated Pressor Response in Relation to Attenuated Muscle Temperature Response during Contraction in Ischemic Heart Failure

Frontiers in Physiology, 2012
It is known that muscle temperature (Tm) increases with exercise. The purpose of this study was to examine if contraction-induced increase in Tm was altered in rats with heart failure (HF) induced by chronic myocardial infraction (MI) as compared with ...
Jianhua eLi, Zhaohui eGao, Jian eLu, Jihong eXing   +3 more
doaj   +1 more source