Results 241 to 250 of about 1,226,791 (296)

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans.

Ageing Res Rev, 2018
Wilkinson DJ, Piasecki M, Atherton PJ.
europepmc   +1 more source

Muscle Fibre Capillarization Is a Critical Factor in Muscle Fibre Hypertrophy During Resistance Exercise Training in Older Men [PDF]

Journal of Cachexia, Sarcopenia and Muscle, 2017
Background Adequate muscle fibre perfusion is critical for the maintenance of muscle mass; it is essential in the rapid delivery of oxygen, nutrients and growth factors to the muscle, stimulating muscle fibre growth. Muscle fibre capillarization is known
Sophie Joanisse, Gianni Parise, Tim Snijders   +2 more
exaly   +3 more sources

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Muscle fibre number is a possible determinant of muscle fibre composition in rats

Acta Physiologica Scandinavica, 1999
The purpose of the present study was to investigate whether the muscle fibre composition is related to the number of muscle fibres. To resolve this issue, we developed fast‐twitch fibre dominant rats (FFDR) by selective breeding and compared the findings to those of control rats (CR) obtained by random breeding.
M, Suwa, T, Nakamura, S, Katsuta
openaire   +2 more sources

Observations on “Detubulated” Muscle Fibres

Nature New Biology, 1972
GLYCEROL treatment of striated muscle1–3 has been widely assumed to be a means of disconnecting the transverse tubular system from the surface membrane. Exposure of a sartorius muscle to Ringer plus 400 mM glycerol followed by a return to Ringer, reduces the membrane capacity of superficial fibres and the muscle is mechanically inactive even though the
J, Zachar, D, Zacharova, R H, Adrian
openaire   +2 more sources

Acetylcholine Receptors in Muscle Fibres

Nature, 1971
There are calculated to be approximately 109 acetylcholine receptors in a frog muscle fibre. This has important implications for theories concerning the nerve to muscle transmission mechanism.
R, Miledi, L T, Potter
openaire   +2 more sources

Laryngeal muscle fibre types

Acta Physiologica Scandinavica, 2005
Summary The internal laryngeal muscles have evolved to subserve the highly specialized functions of airways protection, respiration, and phonation. Their contractile properties, histochemistry, biochemical properties, myosin heavy chain (MyHC) expression and their regulation by nerves and hormones are reviewed and compared with limb ...
openaire   +2 more sources

Studies on muscle fibre splitting in skeletal muscle

Experientia, 1981
Autoradiographic, stereological and histological studies have been carried out to determine the origin of muscle fibre splitting which supposedly occurs during muscle hypertrophy. The results obtained clearly indicate that the supposedly ‘split fibres’ are a transient response probably derived from satellite cells and are not derived from pre-existing ...
G W, Atherton, N T, James, M, Mahon
openaire   +2 more sources

THE STRUCTURE OF THE STRIATED MUSCLE FIBRE

Biological Reviews, 1948
Summary1. The muscle fibre is regarded as a bundle of myofibrils, embedded in a viscous matrix, the sarcoplasm, the whole being surrounded by a delicate sheath, the sarcolemma.2. The sarcolemma is a thin, apparently structureless membrane. Preliminary study with the electron microscope suggests that it may be less than o‐i /u. thick.
openaire   +2 more sources

“Giant” muscle fibres in skeletal muscle of normal pigs

Journal of Comparative Pathology, 1986
Observations made during a growth and development study of the semitendinosus and trapezius muscles of 49 purebred Large White pigs between birth and 128 days of age revealed the presence of giant fibres. The occurrence, histochemical and ultrastructural properties of these giant fibres were investigated.
S E, Handel, N C, Stickland
openaire   +2 more sources