Results 251 to 260 of about 879,135 (289)
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Type III Collagen Deficient EDS IV Producing Muscular Hypotonia with Abnormal Muscle Fibroblasts*
Neuropediatrics, 1991Muscle biopsy and fibroblast culture of a floppy child with Ehlers-Danlos syndrome type IV were studied. Biochemical analysis of the tissue showed drastically reduced amount of collagen type III. Electron microscopic examination of muscle as well as of cultured fibroblasts showed grossly dilated and dominated the cytoplasm endoplasmic reticulum ...
A Fidziańska, F M Pope
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Delay in the maturation of muscle fibers in infants with congenital hypotonia
Journal of the Neurological Sciences, 1978Muscle biopsies of hypotonic children have shown delayed maturation of a fetal type of muscle fibers: subsarcolemmal halo devoid of activity for mitochondrial dehydrogenases, type II predominance and in some cases abnormal dispersion of fiber diameter. Fiber subtypes within group II were also abnormal.
E, Farkas-Bargeton +3 more
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5‐Hydroxyindoles in the Cerebrospinal Fluid of Infants with Down's Syndrome and Muscle Hypotonia
Developmental Medicine & Child Neurology, 1969SUMMARYNo significant differences in the levels of 5‐hydroxyindole acetic acid (5‐HIAA) have been found in the CSF of infants with Down's syndrome, infants with hypotonia associated with mental retardation, and a contiol group. This contrasts with the reported depression of 5‐hydroxytryptamine (5‐HT) in the blood of children with Down's syndrome and ...
V, Dubowitz, K J, Rogers
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Subjective Muscle Weakness and Hypotonia During Clozapine Treatment
Annals of Clinical Psychiatry, 1996Four cases of patients who described an unpleasant subjective experience of weakness and reduced muscle tone during treatment with clozapine are presented. An exacerbation of muscular dystrophy during clozapine treatment is also described. It is hypothesized that these adverse effects are related to the muscle relaxant properties of clozapine.
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Histopathological Background of Muscle Hypotonia in Children with the Prader-Willi Syndrome
Pediatrics International, 1981To elucidate the pathogenesis of hypotonia in the Prader-Willi syndrome, a histological approach towards the five cases was adopted, and traditional histological, histochemical and electron microscopic studies were perfomed. As a result, in light microscopic study type 2 fiber atrophy was found in all the five cases examined, and a combination with ...
Yoshito Hirayama +2 more
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Muscle Biopsy in the Diagnosis of the “Floppy Baby”: Infantile Hypotonia
Developmental Medicine & Child Neurology, 1960New techniques of muscle biopsy, by demonstrating the intramuscular nerve‐endings, can help in the diagnosis of ‘floppy babies’, by providing evidence of disease of the spinal cord or peripheral nerves not demonstrable with classical methods.SUMMARYThe intramuscular nerve endings in biopsy specimens from 25 ‘floppy’ infants were studied by vital ...
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SLEEP, 2023
Abstract Study Objectives Obstructive sleep apnea (OSA), where the upper airway collapses repeatedly during sleep due to inadequate dilator muscle tone, is challenging to treat as current therapies are poorly tolerated or have variable and unpredictable efficacy. We propose a novel, optogenetics-based
Fiona L Knapman +7 more
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Abstract Study Objectives Obstructive sleep apnea (OSA), where the upper airway collapses repeatedly during sleep due to inadequate dilator muscle tone, is challenging to treat as current therapies are poorly tolerated or have variable and unpredictable efficacy. We propose a novel, optogenetics-based
Fiona L Knapman +7 more
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The FASEB Journal, 1989
The neural control of the accessory respiratory muscles regulating upper airway patency is poorly understood. This is particularly true with regard to the declines in electromyographic (EMG) activity of upper airway muscles during sleep.
R, Lydic, H A, Baghdoyan, C W, Zwillich
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The neural control of the accessory respiratory muscles regulating upper airway patency is poorly understood. This is particularly true with regard to the declines in electromyographic (EMG) activity of upper airway muscles during sleep.
R, Lydic, H A, Baghdoyan, C W, Zwillich
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Pediatric Neurology, 2006
Five infants of a Moslem-Arab extended family were evaluated for common and characteristic clinical findings of failure to thrive, extreme muscle weakness, severe motor delay, and moderate to severe cognitive and verbal delay. All children were below the third percentile in weight and height, and three of them had head circumference below the third ...
Miriam, Kutai +5 more
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Five infants of a Moslem-Arab extended family were evaluated for common and characteristic clinical findings of failure to thrive, extreme muscle weakness, severe motor delay, and moderate to severe cognitive and verbal delay. All children were below the third percentile in weight and height, and three of them had head circumference below the third ...
Miriam, Kutai +5 more
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Case 2: Hypotonia and Muscle Weakness since Birth in a 2-year-old Boy
Pediatrics In Review, 20171. Senthil Velan Bhoopalan, MD, PhD* 2. Renu Jain, MD* 1. *Department of Pediatrics, University of Nevada Las Vegas, Las Vegas, NV A 2-year-old boy presents to our clinic with hypotonia and muscle weakness since birth. He has motor developmental delay: he has never crawled because he has had difficulty lifting his head.
Senthil Velan, Bhoopalan, Renu, Jain
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