Results 111 to 120 of about 7,833 (138)

Central Nervous System Effects of Intrathecal Muscle Relaxants in Rats

Anesthesia & Analgesia, 1993
When given for a sufficient time and dose intravenously, neuromuscular blocking drugs eventually can enter the cerebrospinal fluid (CSF). To study the potential pharmacologic consequences of neuromuscular blocking drugs in the CSF, a model was developed in the rat by using an intrathecal infusion of these drugs.
J, Szenohradszky, A J, Trevor, P, Bickler, J E, Caldwell, M L, Sharma, I J, Rampil, R D, Miller   +6 more
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Glyceryl Guaiacolate: a Centrally Acting Muscle Relaxant

Equine Veterinary Journal, 1970
Summary A review of the history of centrally‐acting muscle relaxants has been given. The centrally‐acting muscle relaxant glyceryl guaiacolate has been used extensively in continental Europe and, within recent years, has attracted the attention of North American workers.
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Three novel benzothiazine-fused triazoles as potential centrally acting muscle relaxants

Acta Crystallographica Section C Crystal Structure Communications, 2012
The structures of the novel triazolobenzothiazines 2,4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]thiazin-1-one (IDPH-791), C9H7N3OS, (I), a potential muscle relaxant, its benzoyl derivative, 2-(2-oxo-2-phenylethyl)-2,4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]thiazin-1-one, C20H17N3O4S, (II), and the β-keto ester derivative, ethyl 3-oxo-2-(1 ...
Krishnan, Ravikumar, Balasubramanian, Sridhar, Venkatasubramanian, Hariharakrishnan, Awadesh Narain, Singh   +3 more
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Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems

European Journal of Pharmacology, 1996
The centrally acting muscle relaxant cyclobenzaprine was thought to be an alpha 2-adrenoceptor agonist that reduced muscle tone by decreasing the activity of descending noradrenergic neurons. In the present study, we examined the effects of cyclobenzaprine on descending neurons by measuring the monosynaptic reflex in rats.
H, Kobayashi, Y, Hasegawa, H, Ono
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Etonitazine-induced rigidity and its antagonism by centrally acting muscle relaxants

European Journal of Pharmacology, 1975
Some narcotic drugs have been reported to produce increases in muscle tone in rats. In our laboratory we have found that etonitazine produces a 'lead-pipe' rigidity of the trunk and limb musculature. The reported studies were conducted to characterize etonitazine-induced rigidity more fully, to compare the degree of rigidity with that produced by ...
A, Barnett, J, Goldstein, E, Fiedler, R, Taber   +3 more
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Effects of tizanidine, a centrally acting muscle relaxant, on motor systems

General Pharmacology: The Vascular System, 1986
Effects of tizanidine were studied with special reference to the effect on motor systems. The drug effectively reduced the intercollicular decerebrate rigidity and gamma-activity indirectly recorded from muscle spindle afferent discharges without showing the direct inhibitory effect on muscle spindles in rats.
H, Ono, K, Matsumoto, K, Kato, F, Kato, M, Miyamoto, T, Mori, T, Nakamura, J, Oka, H, Fukuda   +8 more
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Differential sensitivity of the flexor reflex to centrally acting muscle relaxants

Toxicology and Applied Pharmacology, 1960
Abstract Mephenesin, methocarbamol, styramate, and chlorzoxazone are alike in their ability to depress the flexor reflex of the intact chloralose-urethane-anesthetized cat at doses that leave the patellar reflex unchanged.
L B, WITKIN, P, SPITALETTA
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Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) in isolated muscle preparations

General Pharmacology: The Vascular System, 1988
1. Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) were tested in isolated muscle preparations. 2. NC-1200 acted as a Ca-blocker in the guinea pig taenia caecum. The pA2-value was 5.67. 3. In the rabbit aorta, NC-1200 competed with serotonin at serotonin receptors and also shifted the concentration response curves of ...
I, Takayanagi, F, Konno, Y, Sato, H, Uno
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Effects of NK433, a new centrally acting muscle relaxant, on masticatory muscle reflexes in rats

European Journal of Pharmacology, 1996
The effects of (-)-(R)-2-methyl-3-(1-pyrrolidinyl)-4'- trifluoromethylpropiophenone monohydrochloride (NK433), a novel centrally acting muscle relaxant, on masticatory muscle reflexes were investigated in rats. NK433 inhibited the monosynaptic tonic vibration reflex of the masseter muscle and the polysynaptic tonic periodontal masseteric reflex.
Y, Ozawa, C, Komai, K, Sakitama, M, Ishikawa   +3 more
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[Cleavage and biotransformation of the central muscle relaxant chlormezanone].

Die Pharmazie, 1998
Chlormezanone, a chiral centrally acting muscle relaxant, will be cleaved at its S-C-1 bond by an autoprotolytic process. The optimum of chemical stability exists between pH 2 up to pH 9 with a maximum at pH 7.4. The plasma half life at 37 degrees C is 76 h.
H, Oelschläger, W, Klinger, D, Rothley, A, Seeling, H, Bockhard, B, Hofmann, H, Machts, H, Riederer, H, Rackur   +8 more
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