Results 181 to 190 of about 18,960 (304)

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

open access: yesAdvanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen   +7 more
wiley   +1 more source

A smart headband for multimodal physiological monitoring in human exercises

open access: yesAdvanced Science, EarlyView.
A novel smart headband incorporating a thermal‐sensation‐based electronic skin is presented for continuous and accurate multimodal physiological monitoring, including pulse waveforms, total metabolic energy expenditure, heart rate, and forehead temperature, across both static and dynamic daily activities.
Shiqiang Liu   +7 more
wiley   +1 more source

Neuromorphic Motor Control with Electrolyte‐Gated Organic Synaptic Transistors

open access: yesAdvanced Electronic Materials, EarlyView.
Electrolyte‐gated organic synaptic transistor (EGOST)‐based neuromorphic motor control systems integrate sensing, processing, and actuation by mimicking biological synapses. With advantages such as low power consumption, tunable synaptic plasticity, and mechanical flexibility, they are emerging as next‐generation core technologies for real‐time ...
Sung‐Hwan Kim   +3 more
wiley   +1 more source

Prospective Feasibility Study of Laparoscopic and Robotic Distal Gastrectomy for Advanced Gastric Cancer to Verify the Safety of Surgical Proximal Margins

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Ensuring an adequate surgical proximal margin (SPM) is crucial in radical gastrectomy for gastric cancer. However, the lack of tactile feedback in laparoscopic distal gastrectomy (LDG) and robotic distal gastrectomy (RDG) poses challenges in precisely determining tumor boundaries, particularly in advanced gastric cancer, where tumor ...
Rie Makuuchi   +9 more
wiley   +1 more source

Clinical utility of pharyngeal high‐resolution manometry with impedance for upper esophageal sphincter dysfunction in gastroenterology

open access: yesAdvances in Digestive Medicine, EarlyView.
Abstract Pharyngeal high‐resolution manometry with impedance (P‐HRM‐I) is an established assessment method used to evaluate pharyngeal swallowing. It provides precise quantification of swallowing biomechanics that enable the detection of alterations in swallowing physiology.
Mistyka Schar   +5 more
wiley   +1 more source

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