Results 261 to 270 of about 17,821 (298)
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Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems
European Journal of Pharmacology, 1996The centrally acting muscle relaxant cyclobenzaprine was thought to be an alpha 2-adrenoceptor agonist that reduced muscle tone by decreasing the activity of descending noradrenergic neurons. In the present study, we examined the effects of cyclobenzaprine on descending neurons by measuring the monosynaptic reflex in rats.
Yutaka Hasegawa +2 more
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Involvement of imidazoline receptors in the centrally acting muscle-relaxant effects of tizanidine
European Journal of Pharmacology, 2002The centrally acting muscle relaxant tizanidine has an imidazoline structure and binds not only to alpha(2)-adrenoceptors but also to imidazoline receptors. The role of imidazoline receptors in the muscle-relaxant effect of tizanidine was studied using the alpha(2)-adrenoceptor/imidazoline receptor antagonist idazoxan and the alpha(2)-adrenoceptor ...
Yuko Sekiguchi +4 more
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Combination of central and peripheral muscle relaxants in the treatment of post-stroke spasticity
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2019To study the electromiographic (EMG) parameters and to evaluate the therapeutic efficacy of a combination of central (baclofen, baclosan) and peripheral (incobotulotoxinA, xeomin) muscle relaxants in the treatment of post-stroke spasticity (PSS).Ninety-six patients with PSS of upper and lower limbs were divided into 2 groups: the first group (n=56) was
D.N. Frunza +3 more
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Etonitazine-induced rigidity and its antagonism by centrally acting muscle relaxants
European Journal of Pharmacology, 1975Some narcotic drugs have been reported to produce increases in muscle tone in rats. In our laboratory we have found that etonitazine produces a 'lead-pipe' rigidity of the trunk and limb musculature. The reported studies were conducted to characterize etonitazine-induced rigidity more fully, to compare the degree of rigidity with that produced by ...
Allen Barnett +3 more
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Effects of centrally acting muscle relaxants on post-rotatory nystagmus in the rabbit
General Pharmacology: The Vascular System, 19891. The effects of some centrally acting muscle relaxants on the post-rotatory nystagmus induced by rotatory stimulation were investigated in the rabbit, to examine the action of the drugs on vestibular function. 2. Tolperisone-HCl (5-10 mg/kg, i.v.) and baclofen (1-3 mg/kg, i.v.) decreased the number of post-rotatory nystagmus beats dose-dependently ...
H. Miyazaki +3 more
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General Pharmacology: The Vascular System, 1988
1. Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) were tested in isolated muscle preparations. 2. NC-1200 acted as a Ca-blocker in the guinea pig taenia caecum. The pA2-value was 5.67. 3. In the rabbit aorta, NC-1200 competed with serotonin at serotonin receptors and also shifted the concentration response curves of ...
Issei Takayanagi +3 more
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1. Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) were tested in isolated muscle preparations. 2. NC-1200 acted as a Ca-blocker in the guinea pig taenia caecum. The pA2-value was 5.67. 3. In the rabbit aorta, NC-1200 competed with serotonin at serotonin receptors and also shifted the concentration response curves of ...
Issei Takayanagi +3 more
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Pharmacology of a new centrally acting muscle relaxant
Pharmacological Research Communications, 1988István Tarnawa +3 more
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CENTRALLY ACTING MUSCLE RELAXANTS AND SPINAL CORD ACTIVITY [PDF]
Australian Journal of Experimental Biology and Medical Science, 1969 C Raper, DP Crankshaw
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Bioinks and Bioprinting Strategies for Skeletal Muscle Tissue Engineering
Advanced Materials, 2022Mohamadmahdi Samandari +2 more
exaly