Results 261 to 270 of about 18,960 (304)
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Etonitazine-induced rigidity and its antagonism by centrally acting muscle relaxants
European Journal of Pharmacology, 1975Some narcotic drugs have been reported to produce increases in muscle tone in rats. In our laboratory we have found that etonitazine produces a 'lead-pipe' rigidity of the trunk and limb musculature. The reported studies were conducted to characterize etonitazine-induced rigidity more fully, to compare the degree of rigidity with that produced by ...
A, Barnett +3 more
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Effects of tizanidine, a centrally acting muscle relaxant, on motor systems
General Pharmacology: The Vascular System, 1986Effects of tizanidine were studied with special reference to the effect on motor systems. The drug effectively reduced the intercollicular decerebrate rigidity and gamma-activity indirectly recorded from muscle spindle afferent discharges without showing the direct inhibitory effect on muscle spindles in rats.
H, Ono +8 more
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Differential sensitivity of the flexor reflex to centrally acting muscle relaxants
Toxicology and Applied Pharmacology, 1960Abstract Mephenesin, methocarbamol, styramate, and chlorzoxazone are alike in their ability to depress the flexor reflex of the intact chloralose-urethane-anesthetized cat at doses that leave the patellar reflex unchanged.
L B, WITKIN, P, SPITALETTA
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General Pharmacology: The Vascular System, 1988
1. Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) were tested in isolated muscle preparations. 2. NC-1200 acted as a Ca-blocker in the guinea pig taenia caecum. The pA2-value was 5.67. 3. In the rabbit aorta, NC-1200 competed with serotonin at serotonin receptors and also shifted the concentration response curves of ...
I, Takayanagi, F, Konno, Y, Sato, H, Uno
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1. Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) were tested in isolated muscle preparations. 2. NC-1200 acted as a Ca-blocker in the guinea pig taenia caecum. The pA2-value was 5.67. 3. In the rabbit aorta, NC-1200 competed with serotonin at serotonin receptors and also shifted the concentration response curves of ...
I, Takayanagi, F, Konno, Y, Sato, H, Uno
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Effects of NK433, a new centrally acting muscle relaxant, on masticatory muscle reflexes in rats
European Journal of Pharmacology, 1996The effects of (-)-(R)-2-methyl-3-(1-pyrrolidinyl)-4'- trifluoromethylpropiophenone monohydrochloride (NK433), a novel centrally acting muscle relaxant, on masticatory muscle reflexes were investigated in rats. NK433 inhibited the monosynaptic tonic vibration reflex of the masseter muscle and the polysynaptic tonic periodontal masseteric reflex.
Y, Ozawa +3 more
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[Cleavage and biotransformation of the central muscle relaxant chlormezanone].
Die Pharmazie, 1998Chlormezanone, a chiral centrally acting muscle relaxant, will be cleaved at its S-C-1 bond by an autoprotolytic process. The optimum of chemical stability exists between pH 2 up to pH 9 with a maximum at pH 7.4. The plasma half life at 37 degrees C is 76 h.
H, Oelschläger +8 more
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