Results 71 to 80 of about 51,598 (348)

Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins

Advanced Science, EarlyView.
As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na⁺ permeability ratio and its stability over time govern this drift, identify KCR1‐C29D as a reliably inhibitory variant, and outline design principles for ...
Xiao Duan, Chong Zhang, Stanislav Ott, Zhiyi Zhang, Christiane Ruse, Sven Dannhäuser, Robert Jacobi, Nadine Ehmann, Divya Sachidanandan, Georg Nagel, Manfred Heckmann, Robert J. Kittel, Alexander Gottschalk, Adam Claridge‐Chang, Shiqiang Gao   +14 more
wiley   +1 more source

Research progress in the use of botulinum toxin type a for post-stroke spasticity rehabilitation: a narrative review

Annals of Medicine
Background Stroke is a leading cause of long-term disability and death worldwide. Spasticity after stroke seriously affects patients’ quality of life.
Qianwen Xu, Hongbo Xiao, Zongjun Zhu, Yuanyuan Guan, Ya Wang   +4 more
doaj   +1 more source

Measuring muscle tone with isokinetic dynamometer technique in stroke patients

Biomedical Human Kinetics, 2019
Study aim: Increased muscle tone, a common consequence of stroke, has neural and non-neural components. Spasticity is related to the neural component. Non-neural resistance arises from passive stiffness.
Dehno Nasrin Salehi, Sarvestani Fahimeh Kamali, Shariat Abdolhamid, Jaberzadeh Shapour   +3 more
doaj   +1 more source

Muscle Fatigue Enhance Beta Band EMG-EMG Coupling of Antagonistic Muscles in Patients With Post-stroke Spasticity

Frontiers in Bioengineering and Biotechnology, 2020
There is a significant influence of muscle fatigue on the coupling of antagonistic muscles while patients with post-stroke spasticity are characterized by abnormal antagonistic muscle coactivation activities. This study was designed to verify whether the
Le-Jun Wang, Le-Jun Wang, Xiao-Ming Yu, Qi-Neng Shao, Ce Wang, Hua Yang, Shang-Jun Huang, Wen-Xin Niu   +7 more
doaj   +1 more source

The Short-Term Impact of Botulinum Neurotoxin-A on Muscle Morphology and Gait in Children with Spastic Cerebral Palsy

Toxins, 2022
Children with spastic cerebral palsy (SCP) are often treated with intramuscular Botulinum Neurotoxin type-A (BoNT-A). Recent studies demonstrated BoNT-A-induced muscle atrophy and variable effects on gait pathology. This group-matched controlled study in
Nicky Peeters, Eirini Papageorgiou, Britta Hanssen, Nathalie De Beukelaer, Lauraine Staut, Marc Degelaen, Christine Van den Broeck, Patrick Calders, Hilde Feys, Anja Van Campenhout, Kaat Desloovere   +10 more
doaj   +1 more source

A Wearable System Featuring Biomimetic Spatially Distributed Iontronic Sensing Array for Dynamic Monitoring of Deep Tissue Modulus

Advanced Science, EarlyView.
A fully wearable system enables real‐time, dynamic, and accurate monitoring of Young's modulus in multilayer tissues containing deep muscle. It demonstrates high accuracy and robustness across simulations, benchtop validations, and human testing. It quantifies edema severity and tracks muscle stiffness during rest, loaded elbow flexion, rope skipping ...
Zhenning Wang, Chaohua Fang, Ruoyu Sun, Chenghao Feng, Xiaoyuan Wang, Hao Bi, Yidan Wu, Jiangdong Gong, Yuyang Wang, Jiahao Guo, Yu Chang, Huizhi Wang, Tingrui Pan   +12 more
wiley   +1 more source

Spasticity Assessment Based on the Maximum Isometrics Voluntary Contraction of Upper Limb Muscles in Post-stroke Hemiplegia

Frontiers in Neurology, 2019
Background: The assessment of muscle properties is an essential prerequisite in the treatment of post-stroke patients with limb spasticity. Most existing spasticity assessment approaches do not consider the muscle activation with voluntary contraction ...
Hui Wang, Hui Wang, Pingao Huang, Pingao Huang, Xiangxin Li, Oluwarotimi Williams Samuel, Yun Xiang, Yun Xiang, Guanglin Li   +8 more
doaj   +1 more source

Reliability and Validity of the Modified Heckmatt Scale in Evaluating Muscle Changes With Ultrasound in Spasticity

Archives of Rehabilitation Research and Clinical Translation, 2020
Objectives: To determine the reliability and validity of the Modified Heckmatt scale in assessing muscle echotexture in spasticity. Design: Prospective, observational, 2-center study. Two residents and 2 ultrasound experienced staff physicians each rated
Marisa C. Moreta, DO, Alana Fleet, MD, Rajiv Reebye, MD, FRCPC, Gina McKernan, PhD, Michael Berger, MD, PhD, FRCPC, Jordan Farag, MD, Michael C. Munin, MD   +6 more
doaj   +1 more source

Promoting post-stroke recovery through focal or whole body vibration: criticisms and prospects from a narrative review [PDF]

, 2019
Objective: Several focal muscle vibration (fMV) and whole body vibration (WBV) protocols have been designed to promote brain reorganization processes in patients with stroke. However, whether fMV and WBV should be considered helpful tools to promote post-
Bianchini E., Camerota F., Celletti C., Di Piero V., La Torre G., Lakin S., Suppa A., Toscano M.   +7 more
core   +1 more source

Non‐RASopathy Genetic Syndromes Identified as the Molecular Cause of Disease in Patients Previously Diagnosed With Noonan Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan Syndrome (NS) is a clinically and genetically heterogeneous condition characterized by typical facial dysmorphisms, short stature, congenital heart defects, and developmental delays. While variants in genes such as PTPN11, SOS1, and RAF1 account for most genetically confirmed cases, diagnosis is challenging due to phenotypic overlap ...
Gabriela Jeesoo Kim, Alexsandra Christianne Malaquias, Debora Romeo Bertola, Raissa Carneiro Rezende, Laurana De Polli Cellin, Lucas Vieira Lacerda Pires, Ana Maria Santillan‐Vasconez, Antônio Marcondes Lerario, Renata da Cunha Scalco, Alexander Augusto de Lima Jorge   +9 more
wiley   +1 more source