Results 81 to 90 of about 389,322 (305)
Annals of the Rheumatic Diseases, 2002 Gut involvement in inflammatory myositis is rare but causes significant morbidity and mortality.A case of eosinophilic gastroenteritis and polymyositis occurring in the same patient is described. The interface of visceral and striated muscle involvement is discussed.
N, Sofat +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Critical Care, 2021 Background Muscle weakness is a complication of critical illness which hampers recovery. In critically ill mice, supplementation with the ketone body 3-hydroxybutyrate has been shown to improve muscle force and to normalize illness-induced ...
Chloë Goossens +8 more
doaj +1 more source
The Effect of Quadriceps Weakness in Older Adults on Lower Extremity Muscle Function During Gait [PDF]
, 2015 Osteoarthritis is a painful condition that generally causes patients to experience weak quadriceps, abnormal gait kinematics, and difficulty completing daily movements.
Wetli, Alaine
core
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Targeted brain-specific tauopathy compromises peripheral skeletal muscle integrity and function
Aging BrainTauopathies are neurodegenerative disorders in which the pathological intracellular aggregation of the protein tau causes cognitive deficits. Additionally, clinical studies report muscle weakness in populations with tauopathy.
Bryan Alava +6 more
doaj +1 more source
Mechanisms of Skeletal Muscle Weakness
, 2010 Skeletal muscle weakness is an important feature of numerous -pathological conditions and it may also be a component in normal ageing. Decreased muscular strength can be due to decreased muscle mass and/or intrinsic defects in the muscle cells. In this chapter we will discuss decreased force production due to mechanisms intrinsic to skeletal muscle ...
Westerblad, Håkan +2 more
openaire +3 more sources
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
The FNIH-criteria for sarcopenia predict 15-year mortality in ambulatory older men [PDF]
, 2015 Objectives: The Foundation for the National Institutes of Health [FNIH] Sarcopenia Project recently developed new criteria for diagnosis of weakness and low muscle mass in older adults.
De Buyser, Stefanie +6 more
core +1 more source