Results 171 to 180 of about 54,763 (333)

Targeting the SOD1‒MMP‐2‒COLXVII axis: A therapeutic strategy for age‐related tissue degeneration

open access: yesVIEW, EarlyView.
Our work identifies a novel role for MMP‐2 in driving senescence‐associated skin and muscle degeneration through ECM degradation. We demonstrate that inhibiting MMP‐2 activity restores tissue integrity by preserving COLXVII, revealing a new therapeutic pathway for combating oxidative stress‐induced tissue aging. Using both mammalian and nematode models,
Juewon Kim   +8 more
wiley   +1 more source

Focal myasthenia gravis in a 4‐year‐old Chihuahua cross dog presented for apparent vomiting

open access: yesVeterinary Record Case Reports, EarlyView.
Abstract A 4‐year‐old, female, neutered Chihuahua cross was presented with a history of chronic apparent vomiting and coughing. Upon further questioning, regurgitation was suspected rather than vomiting. Conscious thoracic radiographs revealed generalised megaoesophagus.
Martyn A. Wray   +2 more
wiley   +1 more source

Difficulties in social cognitive functioning among pediatric patients with muscular dystrophies. [PDF]

open access: yesFront Psychol, 2023
García I   +5 more
europepmc   +1 more source

Centronuclear myopathy in a Labrador Retriever presenting for evaluation of a ‘bunny‐hopping’ gait

open access: yesVeterinary Record Case Reports, EarlyView.
Abstract A 3‐year‐old female neutered Labrador Retriever presented with a chronic history of ‘bunny‐hopping’ gait, presumed secondary to hip dysplasia. They exhibited moderate exercise intolerance, developing a stiff, short‐strided gait and collapsing into sternal recumbency after a brief period of exercise.
Aishling Lande   +2 more
wiley   +1 more source

Severe Muscular Dystrophy in Girls [PDF]

open access: green, 1965
A W SMITH, C. L. K. McIlwaine
openalex   +1 more source

Primary renal potassium wasting syndrome in a juvenile domestic medium‐hair cat secondary to an atypical distal renal tubular disorder of undetermined molecular origin

open access: yesVeterinary Record Case Reports, EarlyView.
Abstract Renal potassium wasting syndromes, such as Gitelman's syndrome (GS), are well documented in humans but rarely reported in veterinary medicine. This case describes a 6‐month‐old domestic medium‐hair cat presenting with chronic hypokalaemia, polyuria and polydipsia. Diagnostic evaluation revealed hypokalaemia, metabolic alkalosis, hypochloraemia
Kyle L. Granger Jr.   +2 more
wiley   +1 more source

Myonuclear alterations associated with exercise are independent of age in humans

open access: yesThe Journal of Physiology, EarlyView., 2023
Abstract figure legend Structural and mechanical properties of myonuclei in trained young and aged individuals. In skeletal muscle fibres from trained individuals, myonuclei are more spherical, have greater lamin A and are stiffer compared to untrained counterparts.
E. Battey   +15 more
wiley   +1 more source

Laevadosin in Muscular Dystrophy [PDF]

open access: green, 1965
J. N. Walton   +3 more
openalex   +1 more source

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