Results 101 to 110 of about 39,875 (271)

Skeletal muscle‐specific myostatin overexpression promotes muscle oxidative capacity and fatigue resistance in transgenic mice

Experimental Physiology, EarlyView.
Abstract In addition to controlling muscle mass, myostatin may support oxidative metabolism and endurance. Loss of function through gene knockout or post‐natal blockade generally lowers muscle oxidative capacity and increases fatigability. These observations imply that myostatin activation could promote a more oxidative and less fatigable muscle ...
Andy V. Khamoui, Andrea Abraham, Janos Porszasz, Istvan Kovanecz, Silvana Constantinescu, Harry B. Rossiter, Suzanne Reisz‐Porszasz   +6 more
wiley   +1 more source

Duchenne muscular dystrophy: Symptoms, management and prognosis

, 2015
Samuel Alexandre Almeida Honório (Editor).A child with Duchenne Muscular Dystrophy (DMD) faces a childhood and adolescence with a disability that develops gradually. This book intends to expose the problems of children with DMD.
Honório, Samuel
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Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

The value of dog for knowledge of human Duchenne muscular dystrophy: New findings in pathogenesis and therapeutic advances

, 2015
Duchenne muscular dystrophy (DMD) is the most devastating form of inherited muscular dystrophy in men. The loss of dystrophin causes progressive weakness and degeneration of skeletal and cardiac muscle leading to the replacement of muscle by connective ...
Malvestio, Lygia M. [UNESP], de Moraes, Flávio Ruas [UNESP], de Moraes, Julieta R. Engrácia [UNESP], Martins, Isabela M. [UNESP]   +3 more
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Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs [PDF]

, 2018
Muscle strength is a key clinical parameter used to monitor the progression of human muscular dystrophies including Duchenne and Becker muscular dystrophies.
Pollard, Amelia K., Gaffney, CJ, Szewczyk, Nathaniel J., Hewitt, Jennifer E., Lesanpezeshki, Leila, Gaffney, Christopher J., Leila Lesanpezeshki, Vanapalli, Siva A., Pollard, A.K., Hewitt, Jennifer, Amelia K. Pollard, Siva A. Vanapalli, Gaffney, C.J., Szewczyk, N.J., Vanapalli, S.A., Deane, CS, Deane, C.S., Lesanpezeshki, L., Vanapalli, Siva, Timothy Etheridge, Gaffney, Christopher James, Szewczyk, Nathaniel, Etheridge, T, Vanapalli, SA, Jennifer E. Hewitt, Hewitt, J.E., Szewczyk, NJ, Etheridge, Timothy, Colleen S. Deane, Deane, Colleen S., Nathaniel J. Szewczyk, Lesanpezeshki, L, Etheridge, T., Pollard, Amelia, Hewitt, JE, Deane, Colleen, Christopher J. Gaffney, Pollard, AK   +37 more
core   +1 more source

Duchenne Muscular Dystrophy Newborn Screening: Evaluation of a New GSP^® Neonatal Creatine Kinase-MM Kit in a US and Danish Population

International Journal of Neonatal Screening, 2019
Duchenne muscular dystrophy (DMD/Duchenne) is a progressive X-linked disease and is the most common pediatric-onset form of muscular dystrophy, affecting approximately 1:5000 live male births. DNA testing for mutations in the dystrophin gene confirms the
Anne Timonen, Michele Lloyd-Puryear, David M. Hougaard, Liisa Meriö, Pauliina Mäkinen, Ville Laitala, Tuukka Pölönen, Kristin Skogstrand, Annie Kennedy, Sari Airenne, Hanna Polari, Teemu Korpimäki   +11 more
doaj   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Pharmacotherapy of Duchenne Muscular Dystrophy

, 2017
Duchenne muscular dystrophy is a myopathic disease caused by mutations in the dystrophin gene. It is inherited in an X-linked recessive manner from mothers to their sons. The presentation is of progressive muscle weakness in the proximal limb muscles and
Umar, Muhammad Azeem Jalil
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Regimen‐dependent glucocorticoid effects improve muscle performance without altering CNS physiology in mdx mice

The Journal of Physiology, EarlyView.
Abstract figure legend Defining glucocorticoid efficacy in Duchenne muscular dystrophy requires assessment across muscle, central nervous system (CNS), cardiovascular and systemic domains. Here, juvenile mdx mice were treated over 6 weeks, comparing daily and weekly dosing of prednisolone and vamorolone.
Gretel S. Major, Jiayi Chen, Eva van den Berg, Deirdre L. Merry, Angus Lindsay   +4 more
wiley   +1 more source

Cardiac calcium handling in the mouse model of Duchenne Muscular Dystrophy [PDF]

, 2003
The dystrophinopathies are a group of disorders characterised by cellular absence of the membrane stabilising protein, dystrophin. Duchenne muscular dystrophy is the most severe disorder clinically. The deficiency of dystrophin, in the muscular dystrophy
Woolf, Peter James
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