Results 151 to 160 of about 593,469 (313)

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Multitechnological integration advances musculoskeletal regeneration: synergistic progress of organoids, 3D/4D bioprinting, single-cell omics and artificial intelligence. [PDF]

Front Bioeng Biotechnol
Liu Z, Fan H, Zhai T, Ma Z, Yang Y.
europepmc   +1 more source

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Musculoskeletal mechanobiology [PDF]

Connective Tissue Research, 2021
openaire   +2 more sources

Workplace interventions for chronic musculoskeletal disorders: a systematic review. [PDF]

BMJ Open
Skamagki G, Greaves CJ, Shrestha RM, Stathi A.   +3 more
europepmc   +1 more source

Chronic Disease Monitoring Using Advanced Compliant Materials for Bioelectronics

Advanced Electronic Materials, EarlyView.
Compliant bioelectronic systems enable continuous monitoring of chronic disease through soft, stretchable materials and tissue‐conformal designs that support stable electrophysiological, mechanical, and biochemical sensing. Integration of diverse sensing modalities with thoughtful material selection, device architectures, and advanced fabrication ...
Han Kim, Mabel Bartlett, Liyang Wang, Karl Bates, Mengdi He, Myungbo Kim, Carmel Majidi, Tzahi Cohen‐Karni   +7 more
wiley   +1 more source

The Role of Burnout Dimensions, Job Stress, and Work-Life Balance in Multisite Musculoskeletal Pain Among Academicians in Türkiye: A Cross-Sectional Study. [PDF]

Healthcare (Basel)
Kayabınar E, Sağ Zİ, Kayabınar B, Atak E.   +3 more
europepmc   +1 more source

Morbidity Among the Aging Population in Northern Bangladesh: An Epidemiological Study

AGING MEDICINE, EarlyView.
Multimorbidity (≥ 2 chronic diseases) is common among aging populations, yet evidence from Bangladesh remains limited. A cross‐sectional survey of 540 older adults in Northern Bangladesh (June–August 2022) assessed multimorbidity using interviews and logistic regression analysis. Multimorbidity prevalence was 75.74% (95% CI: 71.9%–79.3%).
Md. Abu Sayem, Md. Golam Hossain, Md. Mothashin, Md. Nurul Islam   +3 more
wiley   +1 more source

Circadian rhythm: The hidden "puppet master" behind musculoskeletal disorders. [PDF]

J Orthop Translat
Zhong S, Cheng Y, Li F, Li D, Chang X, Zhang B, Qi P, Li N, Xie X.   +8 more
europepmc   +1 more source