Results 131 to 140 of about 9,385,080 (408)

Moderators and mediators of pain and function outcomes in a new service delivery model for management of knee osteoarthritis in primary care (PARTNER): Secondary exploratory analysis of a randomized controlled trial

Arthritis Care &Research, Accepted Article.
Objective Explore moderators and mediators influenced changes in pain and function in people with knee osteoarthritis (OA) receiving a new model of primary care service delivery (PARTNER), at 12 months (ACTRN12617001595303). Methods Secondary analyses of a cluster randomized controlled trial comparing PARTNER to usual general practitioner‐delivered ...
Abdolhay Farivar, Jocelyn L Bowden, Kim L Bennell, Andrew M Briggs, Stephen J Bunker, Rana S Hinman, Thorlene Egerton, Simon D French, Marie Pirotta, Karen Schuck, Venkatesha Venkatesha, Nicholas A Zwar, David J Hunter   +12 more
wiley   +1 more source

Genetic and phenotypic spectrum in the NONO‐associated syndromic disorder

American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 469-478, February 2023., 2023
Abstract The non‐POU domain‐containing octamer‐binding (NONO) protein is involved in multiple steps of gene regulation such as RNA metabolism and DNA repair. Hemizygous pathogenic variants in the NONO gene were confirmed to cause a rare X‐linked syndromic disorder. Through our in‐house diagnostics and subsequent matchmaking, we identified six unrelated
Franziska Roessler, Anita E. Beck, Ball Susie, Bartolomaeus Tobias, Amber Begtrup, Saskia Biskup, Oana Caluseriu, Norman Delanty, Christine Fröhlich, Marie T. Greally, Maike Karnstedt, Chiara Klöckner, Joanne Kurtzberg, Susanna Schubert, Martin Schulze, Michael Weidenbach, Dominik S. Westphal, Maire White, Cordula M. Wolf, Jacob Zyskind, Bernt Popp, Vincent Strehlow   +21 more
wiley   +1 more source

Enhancing Canine Musculoskeletal Diagnoses: Leveraging Synthetic Image Data for Pre-Training AI-Models on Visual Documentations [PDF]

The examination of the musculoskeletal system in dogs is a challenging task in veterinary practice. In this work, a novel method has been developed that enables efficient documentation of a dog's condition through a visual representation. However, since the visual documentation is new, there is no existing training data.
arxiv   +1 more source

Health-related quality of life as measured with EQ-5D among populations with and without specific chronic conditions: A population-based survey in Shaanxi province, China [PDF]

, 2013
© 2013 Tan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
A Alwan, A Yeung, AL Supina, AS Pickard, CLK Lam, David W. Dowdy, E Pappa, EI Lubetkin, F Gao, F Tian, GH Yang, GLK Hsu, H Picavet, H Sakamaki, Haibo Tu, JB Williamson, JE Ware Jr, JW Hou, JW Shaw, LD Wang, Lingxia Guo, M Javanbakht, MJ Calvert, MTD Dyer, R Brooks, R Rabin, R Tajima, S Sun, Siming Liu, SS Shi, Wenjun Cao, WJ Furlong, YF Yu, Ying Liang, Yongyong Xu, YT Zhang, Zhijun Tan   +36 more
core   +3 more sources

Agreement between patient-reported flares and clinically significant flare status in patients with rheumatoid arthritis in sustained remission: data from the ARCTIC REWIND trials

RMD Open
Objectives To explore the agreement between patient-reported flare status and clinically significant flare status in patients with rheumatoid arthritis (RA) in sustained remission.Method Patients with RA in remission for ≥12 months on stable treatment ...
, Désirée van der Heijde, Gunnstein Bakland, Åse Lexberg, Lena Bugge Nordberg, Siri Lillegraven, Anna-Birgitte Aga, Joseph Sexton, Till Uhlig, Espen A Haavardsholm, Karen Holten, Daniel H Solomon, Ellen Moholt, Hallvard Fremstad, Hilde Haukeland, Nina Paulshus Sundlisæter, Cristina Spada, Kaja E Kjørholt, Christian A Høili, Tor Magne Madland, Inger Johanne Widding Hansen, Inger Myrnes Hansen, Maud-Kristine Aga Ljoså   +22 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Risk of Superficial Fungal Infections in WHIM Syndrome

Dermatology and Therapy
Introduction WHIM syndrome is a rare autosomal dominant inborn error of immunity caused by gain-of-function mutations in the chemokine receptor CXCR4. Patients with WHIM syndrome frequently suffer from an increased risk for bacterial and viral infections,
Jennifer Strong, Rutha Adhanom, Caleb S. Kim, Yoshine Saito, Jasmine C. Meltzer, Patrick Hallaert, Sophia Martinez, Abigail Salancy, Heidi H. Kong, Edward W. Cowen, Leslie Castelo-Soccio, Philip M. Murphy, David H. McDermott, Isaac Brownell   +13 more
doaj   +1 more source

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

Playing-Related Musculoskeletal Disorders of Professional Orchestra Musicians from the North of Portugal: Comparing String and Wind Musicians

Acta Médica Portuguesa, 2017
Introduction: It is well known that musicians are a group prone to suffer from playing-related musculoskeletal disorders. Professional orchestra musicians play for several hours a week and have to fight against pain caused by their profession. The aim of
Cláudia Maria Sousa, Jorge Pereira Machado, Henry Johannes Greten, Daniela Coimbra   +3 more
doaj   +1 more source

Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine

Advanced Functional Materials, EarlyView.
Chiral engineered biomaterials can selectively influence cell behaviors in regenerative medicine. This review covers chiral engineered biomaterials in terms of their fabrication methods, cellular response mechanisms, and applications in directing stem cell differentiation and tissue function.
Yuwen Wang, Xin Zhang, Denghui Xie, Chunying Chen, Zhifeng Huang, Zhong Alan Li   +5 more
wiley   +1 more source