Results 141 to 150 of about 9,516,409 (390)

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

Advanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi, Anastasiya Börsch, Paola Occhetta, Robert Ivanek, Martin Ehrbar, Lisa Krattiger, Philipp Oertle, Marko Loparic, Ivan Martin, Marco Rasponi, Andrea Barbero   +10 more
wiley   +1 more source

P1414: MARROW ADIPOCYTE-ENRICHED NICHE HOSTS AND INFLUENCES A FRACTION OF HEMATOPOIETIC PROGENITORS IN ADULT HIP BONE

HemaSphere, 2022
D. Trivanovic, K. Horas, B. Schlierf, M. Rudert, M. Herrmann   +4 more
doaj   +1 more source

Genome-wide profiling of circulating microRNAs in adolescent idiopathic scoliosis and their relation to spinal deformity severity, and disease pathophysiology

Scientific Reports
Adolescent Idiopathic Scoliosis (AIS) is the most common orthopedic condition requiring surgery, affecting 4% of adolescents. There is currently no proven method or prognostic test to identify symptomatic patients at risk of developing severe scoliosis ...
Nasrin Khatami, Iurie Caraus, Mahamuda Rahaman, Evguenia Nepotchatykh, Mohamed Elbakry, Wesam Elremaly, Anita Franco, Marie Beauséjour, Anne-Marie Laberge, Stefan Parent, Hubert Labelle, Carl-Éric Aubin, Jean Lachaine, Alain Moreau   +13 more
doaj   +1 more source

Exploring differential item functioning in the SF-36 by demographic, clinical, psychological and social factors in an osteoarthritis population [PDF]

, 2013
The SF-36 is a very commonly used generic measure of health outcome in osteoarthritis (OA). An important, but frequently overlooked, aspect of validating health outcome measures is to establish if items work in the same way across subgroup of a ...
A Williams, AJ Dallmeijer, AJ Perkins, B Pollard, BD Zumbo, BD Zumbo, Beth Pollard, C Bombardier, C Lewis, CA McHorney, Diane Dixon, DJ Cooke, F Wolfe, H Swaminathan, J Eachus, JA Teresi, JA Teresi, JA Teresi, JB Bjorner, JB Bjorner, JE Ware, JH Kellgren, M Reckase, Marie Johnston, N Bellamy, NW Scott, OPCS, P Juni, PB Baltes, PK Crane, RO Anderson, SP McKenna, T Covic, WF Velicer, WJ Taylor   +34 more
core   +3 more sources

Therapeutic Implants: Mechanobiologic Enhancement of Osteogenic, Angiogenic, and Myogenic Responses in Human Mesenchymal Stem Cells on 3D‐Printed Titanium Truss

Advanced Healthcare Materials, EarlyView.
This study investigates a synergistic effect between 3D‐printed surface features and mechanical micro‐strain in enhancing the osteogenic, angiogenic, and myogenic responses of human mesenchymal stem cells (hMSCs). Load‐induced mechanotransduction, facilitated by the implant's architectural design, significantly amplifies hMSC differentiation.
Se‐Hwan Lee, Ali Kiapour, Brendan D. Stoeckl, Ellen Y. Zhang, Matthew R. Begley, Jarod Oldham, Lewis Harrison, Jessee Hunt, Robert L. Mauck, Su Chin Heo   +9 more
wiley   +1 more source

SMPDL3B a novel biomarker and therapeutic target in myalgic encephalomyelitis

Journal of Translational Medicine
Background Sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B) is emerging as a potential biomarker and therapeutic target in myalgic encephalomyelitis (ME), a complex multisystem disorder characterized by immune dysfunction, metabolic disturbances ...
Bita Rostami-Afshari, Wesam Elremaly, Anita Franco, Mohamed Elbakry, Marie-Yvonne Akoume, Ines Boufaied, Atefeh Moezzi, Corinne Leveau, Pierre Rompré, Christian Godbout, Olav Mella, Øystein Fluge, Alain Moreau   +12 more
doaj   +1 more source

Occupational Injuries and Illnesses: A Pilot Study of Job-Transfer or Work-Restriction Cases, 2012 [PDF]

, 2014
[Excerpt] The Bureau of Labor Statistics (BLS) conducted a pilot study to learn more about the case circumstances and worker characteristics for occupational injury and illness cases that resulted in days of job transfer or work restriction for workers ...
Bureau of Labor Statistics
core   +2 more sources

The potential therapeutic effects of creatine supplementation on body composition and muscle function in cancer [PDF]

, 2018
Low muscle mass in individuals with cancer has a profound impact on quality of life and independence and is associated with greater treatment toxicity and poorer prognosis.
Fairman, C M, Galvao, D A, Hart, Nicolas H, Kendall, K L, Newton, R U, Taaffe, D R   +5 more
core   +2 more sources

Norbornene Homopolymerization Limits Cell Spreading in Thiol–Ene Photoclick Hydrogels

Advanced Healthcare Materials, EarlyView.
Thiol–norbornene click reactions are often used in the development of cell‐permissive 3D hydrogels. However, ene–ene crosslinks in other thiol–ene systems are known to limit permissivity. This study demonstrates the negative effects of norbornene homopolymerization on 3D cell spreading and circumvents the issue by modulating polymer degree of ...
James L. Gentry, Steven R. Caliari
wiley   +1 more source

Incidence of and survival after surgery for metastatic spine disease: a nationwide register-based study between 1997 and 2020 from Finland

Acta Orthopaedica
Background and purpose: Information on metastatic spine disease (MSD) based on nationwide data on trends and postoperative survival is limited but is needed to optimize treatment in this population. We aimed to assess the incidence of and survival rates
Leevi A Toivonen, Ville Ponkilainen, Jussi P Repo, Ville M Mattila   +3 more
doaj   +1 more source