Results 151 to 160 of about 9,385,080 (408)
Advanced Healthcare Materials, EarlyView.This study develops itaconate‐based polymer microparticles (IA‐MPs) for macrophage‐targeted intracellular delivery, overcoming the limitations of traditional itaconate administration. IA‐MPs achieve controlled release through phagocytosis, reducing pro‐inflammatory cytokine expression and reprogramming macrophage metabolism toward glycolysis.
Kaitlyn E. Woodworth +10 more
wiley +1 more source
Annals of the Rheumatic Diseases, 2020 Objectives To investigate how the first wave of COVID-19 pandemic influenced decisions of rheumatologists and health professionals in rheumatology regarding the management of patients with inflammatory rheumatic and musculoskeletal diseases (RMDs ...
C. Dejaco +10 more
semanticscholar +1 more source
Process and Analysis of Kidney Infiltrates by Flow Cytometry from Murine Lupus Nephritis
Bio-Protocol, 2012 Methods for the isolation and characterization of mononuclear phagocytes from the kidneys of mice with SLE are essential to understand the patho-physiology of the disease. Activation of these cells is associated with the onset of clinical disease in mice
Ramalingam Bethunaickan, Anne Davidson
doaj +1 more source
Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis
Scientific Reports, 2020 Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk is enhanced by dysregulation of adipokines. Low omentin levels were associated with metabolic dysfunction and CV disease in conditions different from ...
Fernanda Genre +24 more
doaj +1 more source
Cells, 2020 Bone infections, also known as infectious osteomyelitis, are accompanied by significant inflammation, osteolysis, and necrosis. Osteoclasts (OCs) are the bone-resorbing cells that work in concert with osteoblasts and osteocytes to properly maintain ...
Philip M. Roper +2 more
doaj +1 more source
Advanced Materials, EarlyView.Biomechanical‐to‐electrical energy conversion devices are uniquely suited for self‐driven physiological information monitoring and powering human–computer interaction systems. These devices based on micro‐/nanoarchitectured inorganic dielectric materials (MNIDMs) have shown ultrahigh electromechanical performance and thus great potential for practical ...
Jia‐Han Zhang +12 more
wiley +1 more source
Undiagnosed mood disorders and sleep disturbances in primary care patients with chronic musculoskeletal pain. [PDF]
, 2013 Objective. The study aims to determine the prevalence of undiagnosed comorbid mood disorders in patients suffering chronic musculoskeletal pain in a primary care setting and to identify sleep disturbances and other associated factors in these ...
Alejandro Salazar +11 more
core +2 more sources
Hydroxyapatite Binding Peptide Lipid Nanoparticles for Biomimetic mRNA Delivery to Bone
Advanced Therapeutics, EarlyView.Targeted delivery of therapeutic mRNA to peripheral tissues, including bone, is currently challenging. In the current work, a hydroxyapatite binding peptide (HABP) is conjugated to mRNA lipid nanoparticles (LNPs). HABP‐LNPs delivered systemically are demonstrated to reduce transfection in the liver and improve transfection in the femurs of mice ...
Joshua A. Choe +6 more
wiley +1 more source
Targeted Delivery for Musculoskeletal Diseases [PDF]
Pharmaceutical Research, 2008 The musculoskeletal system is composed of bone, muscles, tendons, and ligaments. As an essential component of the human anatomy, it serves as the mechanical support for the body and protects vital organs and bone marrow. It also serves as a reserve of ions, especially calcium and phosphate, for the maintenance of serum homeostasis.
openaire +3 more sources
Patient and researcher perspectives on facilitating patient and public involvement in rheumatology research [PDF]
, 2016 No abstract ...
Buckley, Christopher D. +9 more
core +3 more sources