Results 191 to 200 of about 9,385,080 (408)

Modeling Musculoskeletal Disorders in Zebrafish: Advancements in Muscle and Bone Research [PDF]

Zebrafish (Danio rerio) have emerged as a valuable model organism for investigating musculoskeletal development and the pathophysiology of associated diseases.
Braggio, Michele, Cominacini, Mattia, Dalle Carbonare, Luca, Minoia, Arianna, Pessoa, João, Romanelli, Maria Grazia, Tiso, Natascia, Valenti, Maria Teresa   +7 more
core   +2 more sources

Identification of NIBAN2‐Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis

Advanced Science, EarlyView.
NIBAN2 interacts with the HNRNPU‐cored spliceosome complex and alters its components to regulate the alternative splicing of RUNX2, which ultimately cause an increase in functional RUNX2 (nuclear localization sequence complete) but a decrease in dysfunctional Runx2 (exon 6‐exclusive) isoforms to reinforce osteoblast differentiation.
Sheng Zhang, Zhiqiang Yang, Yuanlong Xie, Yufeng Zhang, Zhe Chen, Xuan Lv, Zhouming Deng, Zan Huang, Lin Cai, Renxiong Wei   +9 more
wiley   +1 more source

Hypothalamus Regulates Anabolic Metabolism of Articular Cartilage Superficial Chondrocytes through PGE2 Skeletal Interoception

Advanced Science, EarlyView.
Hypothalamus sympathetic norepinephrine inhibits regeneration of articular cartilage. Mechanical loading on bone during animal activity elevates PGE2 skeletal interoception to promote an anabolic renewal of the superficial membrane by downregulation of norepinephrine for articular cartilage proper thickness and integrity.
Ziyi Wang, Xuequan Han, Jiawen Xu, Weixin Zhang, Kalp Patel, Jinjian Zheng, Mei Wan, Junying Zheng, Xu Cao   +8 more
wiley   +1 more source

Therapeutic serum level for adalimumab in rheumatoid arthritis: explorative analyses of data from a randomised phase III trial

RMD Open
Objectives The objectives of this study are to identify a therapeutic serum level for adalimumab associated with remission and low disease activity in patients with rheumatoid arthritis.Methods Associations between serum adalimumab trough levels and ...
Joseph Sexton, Daniel Aletaha, Eirik Klami Kristianslund, Espen Andre Haavardsholm, Nils Bolstad, Johanna Elin Gehin, Silje Watterdal Syversen, David John Warren, Guro Løvik Goll, Ingrid Jyssum, Rolf Anton Klaasen   +10 more
doaj   +1 more source

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen   +11 more
wiley   +1 more source

Classification of Neurological Gait Disorders Using Multi-task Feature Learning [PDF]

arXiv, 2016
As our population ages, neurological impairments and degeneration of the musculoskeletal system yield gait abnormalities, which can significantly reduce quality of life. Gait rehabilitative therapy has been widely adopted to help patients maximize community participation and living independence.
arxiv  

Suspended Tissue Open Microfluidic Patterning (STOMP)

Advanced Science, EarlyView.
Suspended Tissue Open Microfluidic Patterning (STOMP) is a method that enables precise spatial patterning within a single suspended tissue. By leveraging capillary pinning and open microfluidics, STOMP facilitates the creation of complex tissue interfaces such as diseased‐healthy boundaries and tissue‐tissue junctions. This method integrates mechanical
Amanda J. Haack, Lauren G. Brown, Alex J. Goldstein, Priti Mulimani, Jean Berthier, Asha R. Viswanathan, Irina Kopyeva, Jamison M. Whitten, Ariel Lin, Serena H. Nguyen, Thomas P. Leahy, Ella E. Bouker, Ruby M. Padgett, Natalie A. Mazzawi, Jodie C. Tokihiro, Ross C. Bretherton, Aaliyah Wu, Stephen J. Tapscott, Cole A. DeForest, Tracy E. Popowics, Erwin Berthier, Nathan J. Sniadecki, Ashleigh B. Theberge   +22 more
wiley   +1 more source

Toward Cost-efficient Adaptive Clinical Trials in Knee Osteoarthritis with Reinforcement Learning [PDF]

arXiv
Osteoarthritis (OA) is the most common musculoskeletal disease, with knee OA (KOA) being one of the leading causes of disability and a significant economic burden. Predicting KOA progression is crucial for improving patient outcomes, optimizing healthcare resources, studying the disease, and developing new treatments.
arxiv  

Learning Bone Suppression from Dual Energy Chest X-rays using Adversarial Networks [PDF]

arXiv, 2018
Suppressing bones on chest X-rays such as ribs and clavicle is often expected to improve pathologies classification. These bones can interfere with a broad range of diagnostic tasks on pulmonary disease except for musculoskeletal system. Current conventional method for acquisition of bone suppressed X-rays is dual energy imaging, which captures two ...
arxiv  

The Cost of Care: New Insights into Healthcare Spending Growth [PDF]

, 2017
[Excerpt] The Bureau of Labor Statistics (BLS) is celebrating the first anniversary of experimental disease-based price indexes, which adjust expenditures on disease for inflation.
Bradley, Ralph
core   +1 more source