Results 181 to 190 of about 46,517 (314)

Intermountain Acoustic Musician, Volume 23 Number 8, August 2006

open access: yes, 2006
Salt Lake City, UT: International Bluegrass Association; The Intermountain Acoustic Music Association is a member of the International Bluegrass Music Association and Folk Alliance, the North American folk music and dance alliance. Intermountain Acoustic
Intermountain Acoustic Music Association
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Intermountain Acoustic Musician, Volume 8 Number 1, January 1991

open access: yes, 1988
Salt Lake City, UT: International Bluegrass Association; The Intermountain Acoustic Music Association is a member of the International Bluegrass Music Association and Folk Alliance, the North American folk music and dance alliance. Intermountain Acoustic
Intermountain Acoustic Music Association
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

The Trading Musician

open access: yes, 2005
The Trading Musician, Dobrowolsky, Tom
core  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

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